Bacterial Manipulation of Innate Immunity to Promote Infection

Overview

Journal Nat Rev Microbiol

Specialties Infectious Diseases
Microbiology

Date 2010 Jan 16

PMID 20075926

Citations 131

Authors

Lautaro Diacovich

Jean-Pierre Gorvel

Affiliations

Soon will be listed here.

Abstract

The mammalian innate immune response provides a barrier against invading pathogens. Innate immune mechanisms are used by the host to respond to a range of bacterial pathogens in an acute and conserved fashion. Host cells express pattern recognition receptors that sense pathogen-associated molecular patterns. After detection, an arsenal of antimicrobial mechanisms is deployed to kill bacteria in infected cells. Innate immunity also stimulates antigen-specific responses mediated by the adaptive immune system. In response, pathogens manipulate host defence mechanisms to survive and eventually replicate. This Review focuses on the control of host innate immune responses by pathogenic intracellular bacteria.

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