Prevalence and Associated Factors of Self-medication in Worldwide Pregnant Women: Systematic Review and Meta-analysis

Overview

Journal BMC Public Health

Publisher Biomed Central

Specialty Public Health

Date 2024 Jan 26

PMID 38279083

Authors

Afaf Bouqoufi

Lahlou Laila

Said Boujraf

Fatima Ait El Hadj

Rachid Razine

Redouane Abouqal

Youssef Khabbal

Affiliations

Soon will be listed here.

Abstract

Background: Self-medication during pregnancy is of great interest. The use of drugs during pregnancy requires a careful reflection on the benefits to the mother and the risks to the fetus. Selecting a drug or drugs for treating pregnant women can be difficult for clinicians owing to the various pharmacokinetic and physiological changes encountered during pregnancy. This systematic review and meta-analysis aimed to estimate the pooled prevalence of self-medication and associated factors among women during pregnancy.

Methods: Searches were carried out at PubMed, Science Direct, Web of Science, and Google Scholar. The quality of the studies and the risk of bias were analyzed using the Joanna Briggs Critical Appraisal Checklist for Analytical Cross-Sectional Studies instrument. The extracted data were tabulated and analyzed qualitatively and quantitatively through meta-analysis.

Results: The overall prevalence of self-medication among pregnant women was 44.50% (95% CI: 38.92-50.23). Subgroup analyses showed differences in self-medication prevalence influenced by region, county income, and study design. The Heterogeneity, assessed by the statistical test I2 varied from 96 to 99% and was statistically significant. The result of this funnel plot showed that the funnel plot was symmetry with p-value = 0.36, and there is no publication bias.

Conclusion: The results obtained from this study showed that the prevalence of self-medication among pregnant women is relatively high. This requires effective measures and interventions to reduce self-medication.

Trial Registration: ID = CRD42022312333 .

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References

Alsous M, Al-Azzam S, Nusair M, Alnahar S, Obeidat N . Self-medication among pregnant women attending outpatients' clinics in northern Jordan-a cross-sectional study. Pharmacol Res Perspect. 2021; 9(2):e00735. PMC: 7914772. DOI: 10.1002/prp2.735. View

Lupattelli A, Spigset O, Twigg M, Zagorodnikova K, Mardby A, Moretti M . Medication use in pregnancy: a cross-sectional, multinational web-based study. BMJ Open. 2014; 4(2):e004365. PMC: 3927801. DOI: 10.1136/bmjopen-2013-004365. View

Liberati A, Altman D, Tetzlaff J, Mulrow C, Gotzsche P, Ioannidis J . The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Ann Intern Med. 2009; 151(4):W65-94. DOI: 10.7326/0003-4819-151-4-200908180-00136. View

J Marwa K, Njalika A, Ruganuza D, Katabalo D, Kamugisha E . Self-medication among pregnant women attending antenatal clinic at Makongoro health centre in Mwanza, Tanzania: a challenge to health systems. BMC Pregnancy Childbirth. 2018; 18(1):16. PMC: 5759229. DOI: 10.1186/s12884-017-1642-8. View

Baghianimoghadam M, Mojahed S, Baghianimoghadam M, Yousefi N, Zolghadr R . Attitude and practice of pregnant women regarding self-medication in Yazd, Iran. Arch Iran Med. 2013; 16(10):580-3. DOI: 0131610/AIM.006. View

Ocan M, Obuku E, Bwanga F, Akena D, Richard S, Ogwal-Okeng J . Household antimicrobial self-medication: a systematic review and meta-analysis of the burden, risk factors and outcomes in developing countries. BMC Public Health. 2015; 15:742. PMC: 4522083. DOI: 10.1186/s12889-015-2109-3. View

Barker T, Migliavaca C, Stein C, Colpani V, Falavigna M, Aromataris E . Conducting proportional meta-analysis in different types of systematic reviews: a guide for synthesisers of evidence. BMC Med Res Methodol. 2021; 21(1):189. PMC: 8451728. DOI: 10.1186/s12874-021-01381-z. View

Loebstein R, Lalkin A, Koren G . Pharmacokinetic changes during pregnancy and their clinical relevance. Clin Pharmacokinet. 1997; 33(5):328-43. DOI: 10.2165/00003088-199733050-00002. View

Ebrahimi H, Atashsokhan G, Amanpour F, Hamidzadeh A . Self-medication and its risk factors among women before and during pregnancy. Pan Afr Med J. 2017; 27:183. PMC: 5579420. DOI: 10.11604/pamj.2017.27.183.10030. View

10.

Hassoun-Barhamji R, Raia Barjat T, Chauleur C . [In the Era Of Self-Medication, What Do Pregnant Women Know about Anti-Inflammatory Drugs?]. Therapie. 2015; 70(4):369-76. DOI: 10.2515/therapie/2015019. View

11.

Mohamed Ibrahim O, Ibrahim R, Al-Tameemi N, Ebaed S, AlMazrouei N, Riley K . Evaluation of the use and attitudes of pregnant and postpartum women towards medicine utilisation during pregnancy in the United Arab Emirates: A national cross-sectional study. Int J Clin Pract. 2021; 75(9):e14344. DOI: 10.1111/ijcp.14344. View

12.

Raheel H, Alsakran S, Alghamdi A, Ajarem M, Alsulami S, Mahmood A . Antibiotics and over the counter medication use and its correlates among Arab pregnant women visiting a tertiary care hospital in Riyadh, Saudi Arabia. Pak J Med Sci. 2017; 33(2):452-456. PMC: 5432722. DOI: 10.12669/pjms.332.12376. View

13.

Mohseni M, Azami-Aghdash S, Sheyklo S, Moosavi A, Nakhaee M, Pournaghi-Azar F . Prevalence and Reasons of Self-Medication in Pregnant Women: A Systematic Review and Meta-Analysis. Int J Community Based Nurs Midwifery. 2018; 6(4):272-284. PMC: 6226611. View

14.

Alonso-Castro A, Ruiz-Padilla A, Ruiz-Noa Y, Alba-Betancourt C, Dominguez F, Ibarra-Reynoso L . Self-medication practice in pregnant women from central Mexico. Saudi Pharm J. 2018; 26(6):886-890. PMC: 6128711. DOI: 10.1016/j.jsps.2018.03.008. View

15.

Lunardi-Maia T, Schuelter-Trevisol F, Galato D . [Medication use during the first trimester of pregnancy: drug safety and adoption of folic acid and ferrous sulphate]. Rev Bras Ginecol Obstet. 2014; 36(12):541-7. DOI: 10.1590/so100-720320140005051. View

16.

Ahmed S, Sundby J, Aragaw Y, Abebe F . Self-Medication and Safety Profile of Medicines Used among Pregnant Women in a Tertiary Teaching Hospital in Jimma, Ethiopia: A Cross-Sectional Study. Int J Environ Res Public Health. 2020; 17(11). PMC: 7312933. DOI: 10.3390/ijerph17113993. View

17.

Zaki N, Albarraq A . Use, attitudes and knowledge of medications among pregnant women: A Saudi study. Saudi Pharm J. 2014; 22(5):419-28. PMC: 4246410. DOI: 10.1016/j.jsps.2013.09.001. View

18.

Kumar N, Kanchan T, Unnikrishnan B, Rekha T, Mithra P, Kulkarni V . Perceptions and practices of self-medication among medical students in coastal South India. PLoS One. 2013; 8(8):e72247. PMC: 3756058. DOI: 10.1371/journal.pone.0072247. View

19.

Leke A, Dolk H, Loane M, Casson K, Maboh N, Maeya S . First trimester medication use in pregnancy in Cameroon: a multi-hospital survey. BMC Pregnancy Childbirth. 2018; 18(1):450. PMC: 6245902. DOI: 10.1186/s12884-018-2081-x. View

20.

Dawes M, Chowienczyk P . Drugs in pregnancy. Pharmacokinetics in pregnancy. Best Pract Res Clin Obstet Gynaecol. 2002; 15(6):819-26. DOI: 10.1053/beog.2001.0231. View