Metabolic Heterogeneity in Cancer

Overview

Journal Nat Metab

Publisher Springer Nature

Specialty Endocrinology

Date 2024 Jan 24

PMID 38267631

Authors

Margherita Demicco

Xiao-Zheng Liu

Katharina Leithner

Sarah-Maria Fendt

Affiliations

Soon will be listed here.

Abstract

Cancer cells rewire their metabolism to survive during cancer progression. In this context, tumour metabolic heterogeneity arises and develops in response to diverse environmental factors. This metabolic heterogeneity contributes to cancer aggressiveness and impacts therapeutic opportunities. In recent years, technical advances allowed direct characterisation of metabolic heterogeneity in tumours. In addition to the metabolic heterogeneity observed in primary tumours, metabolic heterogeneity temporally evolves along with tumour progression. In this Review, we summarize the mechanisms of environment-induced metabolic heterogeneity. In addition, we discuss how cancer metabolism and the key metabolites and enzymes temporally and functionally evolve during the metastatic cascade and treatment.

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