Engineered Nanodrug Targeting Oxidative Stress for Treatment of Acute Kidney Injury

Overview

Journal Exploration (Beijing)

Specialty Biomedical Engineering

Date 2024 Jan 24

PMID 38264689

Authors

Liwen Li

Yining Shen

Zhongmin Tang

Yuwen Yang

Zi Fu

Dalong Ni

Xiaojun Cai

Affiliations

Soon will be listed here.

Abstract

Acute kidney injury (AKI) is a clinical syndrome characterized by a rapid decline in renal function, and is associated with a high risk of death. Many pathological changes happen in the process of AKI, including crucial alterations to oxidative stress levels. Numerous efforts have thus been made to develop effective medicines to scavenge excess reactive oxygen species (ROS). However, researchers have encountered several significant challenges, including unspecific biodistribution, high biotoxicity, and in vivo instability. To address these problems, engineered nanoparticles have been developed to target oxidative stress and treat AKI. This review thoroughly discusses the methods that empower nanodrugs to specifically target the glomerular filtration barrier and presents the latest achievements in engineering novel ROS-scavenging nanodrugs in clustered sections. The analysis of each study's breakthroughs and imperfections visualizes the progress made in developing effective nanodrugs with specific biodistribution and oxidative stress-targeting capabilities. This review fills the blank of a comprehensive outline over current progress in applying nanotechnology to treat AKI, providing potential insights for further research.

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