Acute Effects of High Intensity Interval Training Versus Moderate Intensity Continuous Training on Haemostasis in Patients with Coronary Artery Disease

Overview

Journal Sci Rep

Specialty Science

Date 2024 Jan 23

PMID 38263210

Authors

Daniel Kosuta

Marko Novakovic

Mojca Bozic Mijovski

Borut Jug

Affiliations

Soon will be listed here.

Abstract

Exercise training is associated with an acute net increase in coagulation, which may increase the risk of atherothrombosis in coronary artery disease (CAD) patients. We sought to compare the acute haemostatic effects of a bout of moderate-intensity continuous (MICT) and high-intensity interval training (HIIT) in patients with CAD. Patients after a recent myocardial infarction were randomized into a HIIT or MICT session of exercise training on a stationary bike. Blood was sampled at baseline, after the exercise bout and after a one-hour resting period. We measured overall haemostatic potential (OHP), overall coagulation potential (OCP), fibrinogen, D-dimer and von Willebrand factor (vWF) and calculated overall fibrinolytic potential (OFP). Linear mixed models for repeated measures were constructed to assess the treatment effect. A total of 117 patients were included. OCP, OHP, fibrinogen, D-dimer and vWF significantly increased after exercise and returned to baseline after a one-hour rest, OFP decreased after exercise and returned to baseline levels after a one-hour rest. Linear mixed models showed a significant difference between HIIT and MICT in fibrinogen (p 0.043) and D-dimer (p 0.042). Our study has shown that an exercise bout is associated with a transient procoagulant state in patients with CAD, with similar exercise-induced haemostatic changes for HIIT and MICT.

References

De Luca G, Verdoia M, Cassetti E, Schaffer A, Cavallino C, Bolzani V . High fibrinogen level is an independent predictor of presence and extent of coronary artery disease among Italian population. J Thromb Thrombolysis. 2010; 31(4):458-63. DOI: 10.1007/s11239-010-0531-z. View

Maino A, Rosendaal F, Algra A, Peyvandi F, Siegerink B . Hypercoagulability Is a Stronger Risk Factor for Ischaemic Stroke than for Myocardial Infarction: A Systematic Review. PLoS One. 2015; 10(8):e0133523. PMC: 4529149. DOI: 10.1371/journal.pone.0133523. View

Thomas D, Roberts H . Hypercoagulability in venous and arterial thrombosis. Ann Intern Med. 1997; 126(8):638-44. DOI: 10.7326/0003-4819-126-8-199704150-00009. View

Cossette S, Maheu-Cadotte M, Mailhot T, Fontaine G, Cournoyer A, Cournoyer C . Sex- and Gender-Related Factors Associated With Cardiac Rehabilitation Enrollment: A SECONDARY ANALYSIS AMONG SYSTEMATICALLY REFERRED PATIENTS. J Cardiopulm Rehabil Prev. 2018; 39(4):259-265. DOI: 10.1097/HCR.0000000000000364. View

Verschueren S, Eskes A, Maaskant J, Roest A, Latour C, Scholte Op Reimer W . The effect of exercise therapy on depressive and anxious symptoms in patients with ischemic heart disease: A systematic review. J Psychosom Res. 2018; 105:80-91. DOI: 10.1016/j.jpsychores.2017.11.018. View

Rognmo O, Hetland E, Helgerud J, Hoff J, Slordahl S . High intensity aerobic interval exercise is superior to moderate intensity exercise for increasing aerobic capacity in patients with coronary artery disease. Eur J Cardiovasc Prev Rehabil. 2004; 11(3):216-22. DOI: 10.1097/01.hjr.0000131677.96762.0c. View

Chan M, Andreotti F, Becker R . Hypercoagulable states in cardiovascular disease. Circulation. 2008; 118(22):2286-97. DOI: 10.1161/CIRCULATIONAHA.108.778837. View

Tofler G . Triggering and the pathophysiology of acute coronary syndromes. Am Heart J. 1997; 134(5 Pt 2):S55-61. View

Lin X, El-Sayed M, Waterhouse J, Reilly T . Activation and disturbance of blood haemostasis following strenuous physical exercise. Int J Sports Med. 1999; 20(3):149-53. DOI: 10.1055/s-2007-971109. View

10.

Smith J . Effects of strenuous exercise on haemostasis. Br J Sports Med. 2003; 37(5):433-5. PMC: 1751362. DOI: 10.1136/bjsm.37.5.433. View

11.

Koenig W, Rothenbacher D, Hoffmeister A, Griesshammer M, Brenner H . Plasma fibrin D-dimer levels and risk of stable coronary artery disease: results of a large case-control study. Arterioscler Thromb Vasc Biol. 2001; 21(10):1701-5. DOI: 10.1161/hq1001.097020. View

12.

Yue T, Wang Y, Liu H, Kong Z, Qi F . Effects of High-Intensity Interval vs. Moderate-Intensity Continuous Training on Cardiac Rehabilitation in Patients With Cardiovascular Disease: A Systematic Review and Meta-Analysis. Front Cardiovasc Med. 2022; 9:845225. PMC: 8904881. DOI: 10.3389/fcvm.2022.845225. View

13.

Peng Y, Wang H, Li Y, Huang B, Huang F, Xia T . Relation between admission plasma fibrinogen levels and mortality in Chinese patients with coronary artery disease. Sci Rep. 2016; 6:30506. PMC: 4960561. DOI: 10.1038/srep30506. View

14.

Acil T, Atalar E, Sahiner L, Kaya B, Haznedaroglu I, Tokgozoglu L . Effects of acute exercise on fibrinolysis and coagulation in patients with coronary artery disease. Int Heart J. 2007; 48(3):277-85. DOI: 10.1536/ihj.48.277. View

15.

Womack C, Nagelkirk P, Coughlin A . Exercise-induced changes in coagulation and fibrinolysis in healthy populations and patients with cardiovascular disease. Sports Med. 2003; 33(11):795-807. DOI: 10.2165/00007256-200333110-00002. View

16.

Spiel A, Gilbert J, Jilma B . von Willebrand factor in cardiovascular disease: focus on acute coronary syndromes. Circulation. 2008; 117(11):1449-59. DOI: 10.1161/CIRCULATIONAHA.107.722827. View

17.

de Maat M, Pietersma A, Kofflard M, Sluiter W, Kluft C . Association of plasma fibrinogen levels with coronary artery disease, smoking and inflammatory markers. Atherosclerosis. 1996; 121(2):185-91. DOI: 10.1016/0021-9150(95)05716-1. View

18.

Gaalema D, Savage P, Leadholm K, Rengo J, Naud S, Priest J . Clinical and Demographic Trends in Cardiac Rehabilitation: 1996-2015. J Cardiopulm Rehabil Prev. 2019; 39(4):266-273. PMC: 6594875. DOI: 10.1097/HCR.0000000000000390. View

19.

Hannan A, Hing W, Simas V, Climstein M, Coombes J, Jayasinghe R . High-intensity interval training versus moderate-intensity continuous training within cardiac rehabilitation: a systematic review and meta-analysis. Open Access J Sports Med. 2018; 9:1-17. PMC: 5790162. DOI: 10.2147/OAJSM.S150596. View

20.

Green D, Smith K . Effects of Exercise on Vascular Function, Structure, and Health in Humans. Cold Spring Harb Perspect Med. 2017; 8(4). PMC: 5880156. DOI: 10.1101/cshperspect.a029819. View