Hypercoagulability Is a Stronger Risk Factor for Ischaemic Stroke Than for Myocardial Infarction: A Systematic Review

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2015 Aug 8

PMID 26252207

Citations 24

Authors

Alberto Maino

Frits R Rosendaal

Ale Algra

Flora Peyvandi

Bob Siegerink

Affiliations

Soon will be listed here.

Abstract

Background And Purpose: Hypercoagulability increases the risk of arterial thrombosis; however, this effect may differ between various manifestations of arterial disease.

Methods: In this study, we compared the effect of coagulation factors as measures of hypercoagulability on the risk of ischaemic stroke (IS) and myocardial infarction (MI) by performing a systematic review of the literature. The effect of a risk factor on IS (relative risk for IS, RRIS) was compared with the effect on MI (RRMI) by calculating their ratio (RRR = RRIS/RRMI). A relevant differential effect was considered when RRR was >1+ its own standard error (SE) or <1-SE.

Results: We identified 70 publications, describing results from 31 study populations, accounting for 351 markers of hypercoagulability. The majority (203/351, 58%) had an RRR greater than 1. A larger effect on IS risk than MI risk (RRE>1+1SE) was found in 49/343 (14%) markers. Of these, 18/49 (37%) had an RRR greater than 1+2SE. On the opposite side, a larger effect on MI risk (RRR<1-1SE) was found in only 17/343 (5%) markers.

Conclusions: These results suggest that hypercoagulability has a more pronounced effect on the risk of IS than that of MI.

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