The Effect of Extract on Serum Metabolites of Angus Crossbreed Steers with Metabolomics

Overview

Journal Metabolites

Publisher MDPI

Date 2024 Jan 22

PMID 38248861

Authors

Ziqi Deng

Baoyun Wu

Xin Yi

Jinglei Ma

Yue Liu

Luiz Gustavo Nussio

Qingxiang Meng

Zhenming Zhou

Hao Wu

Affiliations

Soon will be listed here.

Abstract

This study was conducted to explore the potential effect of extract (YSE) on the metabolism of beef cattle. Thirty Angus crossbreed steers were selected, with an initial mean body weight of 506.6 ± 33.3 kg, and assigned to two treatments: a diet with no additives (CON group) and a diet supplemented with 1.75 g/kg of YSE (YSE group) (on a dry matter basis). The experiment lasted for 104 days, with 14 days for adaptation. The results showed that adding YSE could significantly improve the average daily gain (ADG) from 1 to 59 d (15.38%) ( = 0.01) and 1 to 90 d (11.38%) ( < 0.01), as well as dry matter digestibility (DMD) (0.84%) ( < 0.05). The contents of alanine aminotransferase, aspartate aminotransferase, and bilirubin and the total antioxidant capacity were increased and blood urea was reduced in the YSE group, compared to the CON group ( < 0.05). Both the glycerophospholipids and bile acids, including phosphocholine, glycerophosphocholine, PC(15:0/18:2(9Z,12Z)), PE(18:0/20:3(5Z,8Z,11Z)), PE(18:3(6Z,9Z,12Z)/P-18:0), LysoPC(15:0), LysoPC(17:0), LysoPC(18:0), LysoPC(20:5(5Z,8Z,11Z,14Z,17Z)), deoxycholic acid, glycocholic acid, and cholic acid, were upregulated by the addition of YSE. In summary, YSE may improve the ADG by increasing the blood total antioxidant capacity and glycerophospholipid synthesis, maintaining steers under a healthy status that is beneficial for growth. Furthermore, YSE may also increase the expression of bile acid synthesis, thereby promoting DMD, which, in turn, offers more nutrients available for growth.

References

Kholif A . A Review of Effect of Saponins on Ruminal Fermentation, Health and Performance of Ruminants. Vet Sci. 2023; 10(7). PMC: 10385484. DOI: 10.3390/vetsci10070450. View

Thomas F, Hehemann J, Rebuffet E, Czjzek M, Michel G . Environmental and gut bacteroidetes: the food connection. Front Microbiol. 2011; 2:93. PMC: 3129010. DOI: 10.3389/fmicb.2011.00093. View

Li Z, Agellon L, Allen T, Umeda M, Jewell L, Mason A . The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis. Cell Metab. 2006; 3(5):321-31. DOI: 10.1016/j.cmet.2006.03.007. View

Narvaez N, Wang Y, McAllister T . Effects of extracts of Humulus lupulus (hops) and Yucca schidigera applied alone or in combination with monensin on rumen fermentation and microbial populations in vitro. J Sci Food Agric. 2013; 93(10):2517-22. DOI: 10.1002/jsfa.6068. View

Alghirani M, Chung E, Sabri D, Tahir M, Kassim N, Kamalludin M . Can Be Used to Enhance the Growth Performance, Nutrient Digestibility, Gut Histomorphology, Cecal Microflora, Carcass Characteristic, and Meat Quality of Commercial Broilers Raised under Tropical Conditions?. Animals (Basel). 2021; 11(8). PMC: 8388359. DOI: 10.3390/ani11082276. View

Dai Z, Wang H, Liu J, Zhang H, Li Q, Yu X . Comparison of the Effects of , , and on Growth Performance, Immunity, Antioxidant Capability, and Intestinal Flora in Broilers. Animals (Basel). 2023; 13(9). PMC: 10177514. DOI: 10.3390/ani13091447. View

Liu W, Zhu La A, Evans A, Gao S, Yu Z, Ma L . Supplementation with Yucca schidigera improves antioxidant capability and immune function and decreases fecal score of dairy calves before weaning. J Dairy Sci. 2021; 104(4):4317-4325. DOI: 10.3168/jds.2020-18980. View

Patra A, Saxena J . The effect and mode of action of saponins on the microbial populations and fermentation in the rumen and ruminant production. Nutr Res Rev. 2009; 22(2):204-19. DOI: 10.1017/S0954422409990163. View

Wang C, Fu R, Xu D, Zuo Q, Liu J, Tang Y . A study integrated metabolomics and network pharmacology to investigate the effects of Shicao in alleviating acute liver injury. J Ethnopharmacol. 2024; 319(Pt 3):117369. DOI: 10.1016/j.jep.2023.117369. View

10.

Alving C . Immunologic aspects of liposomes: presentation and processing of liposomal protein and phospholipid antigens. Biochim Biophys Acta. 1992; 1113(3-4):307-22. DOI: 10.1016/0304-4157(92)90004-t. View

11.

Gass J, Vora H, Hofmann A, Gray G, Khosla C . Enhancement of dietary protein digestion by conjugated bile acids. Gastroenterology. 2007; 133(1):16-23. DOI: 10.1053/j.gastro.2007.04.008. View

12.

Sun D, Jin X, Camerlink I, Tong M, Su J, Zhao F . Effects of Yucca schidigera extract on growth performance and antioxidative function of small intestine in broilers. J Anim Physiol Anim Nutr (Berl). 2019; 103(3):738-746. DOI: 10.1111/jpn.13067. View

13.

Pang K, Chai S, Yang Y, Wang X, Liu S, Wang S . Dietary forage to concentrate ratios impact on yak ruminal microbiota and metabolites. Front Microbiol. 2022; 13:964564. PMC: 9410728. DOI: 10.3389/fmicb.2022.964564. View

14.

Mao X, Dou Y, Fan X, Yu B, He J, Zheng P . The effect of dietary Yucca schidigera extract supplementation on productive performance, egg quality, and gut health in laying hens with Clostridium perfringens and coccidia challenge. Poult Sci. 2023; 102(8):102822. PMC: 10404776. DOI: 10.1016/j.psj.2023.102822. View

15.

de Sousa O, Cooke R, Brandao A, Schubach K, Schumaher T, Bohnert D . Productive and physiological responses of feeder cattle supplemented with Yucca schidigera extract during feedlot receiving. J Anim Sci. 2018; 97(1):208-219. PMC: 6313122. DOI: 10.1093/jas/sky412. View

16.

Fan X, Xiao X, Chen D, Yu B, He J, Yu J . Yucca schidigera extract decreases nitrogen emission via improving nutrient utilisation and gut barrier function in weaned piglets. J Anim Physiol Anim Nutr (Berl). 2021; 106(5):1036-1045. DOI: 10.1111/jpn.13647. View

17.

Bernhard W, Lange R, Graepler-Mainka U, Engel C, Machann J, Hund V . Choline Supplementation in Cystic Fibrosis-The Metabolic and Clinical Impact. Nutrients. 2019; 11(3). PMC: 6471815. DOI: 10.3390/nu11030656. View

18.

Trotta R, Kreikemeier K, Foote S, McLeod K, Harmon D . Influence of Anti-Coccidial Compounds and Phytogenic Saponin Extracts on In Vitro and In Vivo Ruminal Fermentation and Methane Production of Cattle. Animals (Basel). 2023; 13(14). PMC: 10376241. DOI: 10.3390/ani13142308. View

19.

Johnson C, Snelling T, Huntington J, Taylor-Pickard J, Warren H, Sinclair L . Effect of feeding Yucca schidigera extract and a live yeast on the rumen microbiome and performance of dairy cows fed a diet excess in rumen degradable nitrogen. Animal. 2023; 17(10):100967. DOI: 10.1016/j.animal.2023.100967. View

20.

Lin S, Yang X, Yuan P, Yang J, Wang P, Zhong H . Undernutrition Shapes the Gut Microbiota and Bile Acid Profile in Association with Altered Gut-Liver FXR Signaling in Weaning Pigs. J Agric Food Chem. 2019; 67(13):3691-3701. DOI: 10.1021/acs.jafc.9b01332. View