Mitochondrial and Metabolic Dysfunction of Peripheral Immune Cells in Multiple Sclerosis

Overview

Journal J Neuroinflammation

Publisher Biomed Central

Date 2024 Jan 19

PMID 38243312

Authors

Peng-Fei Wang

Fei Jiang

Qiu-Ming Zeng

Wei-Fan Yin

Yue-Zi Hu

Qiao Li

Zhao-Lan Hu

Affiliations

Soon will be listed here.

Abstract

Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by the infiltration of inflammatory cells and demyelination of nerves. Mitochondrial dysfunction has been implicated in the pathogenesis of MS, as studies have shown abnormalities in mitochondrial activities, metabolism, mitochondrial DNA (mtDNA) levels, and mitochondrial morphology in immune cells of individuals with MS. The presence of mitochondrial dysfunctions in immune cells contributes to immunological dysregulation and neurodegeneration in MS. This review provided a comprehensive overview of mitochondrial dysfunction in immune cells associated with MS, focusing on the potential consequences of mitochondrial metabolic reprogramming on immune function. Current challenges and future directions in the field of immune-metabolic MS and its potential as a therapeutic target were also discussed.

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