How Does Exosome Cause Diabetes?

Overview

Journal Hormones (Athens)

Specialty Endocrinology

Date 2024 Jan 17

PMID 38233729

Authors

Fei Hu

Yicong Yu

Hongming Xu

Affiliations

Soon will be listed here.

Abstract

Exosomes are extracellular vesicles that are widely distributed in multiple cell types and circulating body fluids. They have a specific effect on the target cells by releasing different vesicle contents. They have recently been recognized as important means of intercellular communication, being involved, for example, in the development of diabetes by increasing β-cell apoptosis, activating autoimmunity, and regulating cytokines to affect islet β-cell function and insulin sensitivity. An in-depth study of the role of exosome in the pathogenesis of diabetes may therefore provide a novel means of diagnosing and treating diabetes. In this review, we detail how exosome is involved in the development of diabetes.

References

Pont C, Ascaso F, Grzybowski A, Huerva V . Corneal endothelial cell density during diabetes mellitus and ocular diabetes complications treatment. J Fr Ophtalmol. 2020; 43(8):794-798. DOI: 10.1016/j.jfo.2019.12.003. View

Cole J, Florez J . Genetics of diabetes mellitus and diabetes complications. Nat Rev Nephrol. 2020; 16(7):377-390. PMC: 9639302. DOI: 10.1038/s41581-020-0278-5. View

Zhang Y, Bi J, Huang J, Tang Y, Du S, Li P . Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications. Int J Nanomedicine. 2020; 15:6917-6934. PMC: 7519827. DOI: 10.2147/IJN.S264498. View

Kalluri R, LeBleu V . The biology function and biomedical applications of exosomes. Science. 2020; 367(6478). PMC: 7717626. DOI: 10.1126/science.aau6977. View

Bobrie A, Colombo M, Raposo G, Thery C . Exosome secretion: molecular mechanisms and roles in immune responses. Traffic. 2011; 12(12):1659-68. DOI: 10.1111/j.1600-0854.2011.01225.x. View

Robbins P, Morelli A . Regulation of immune responses by extracellular vesicles. Nat Rev Immunol. 2014; 14(3):195-208. PMC: 4350779. DOI: 10.1038/nri3622. View

Cai Z, Yang F, Yu L, Yu Z, Jiang L, Wang Q . Activated T cell exosomes promote tumor invasion via Fas signaling pathway. J Immunol. 2012; 188(12):5954-61. DOI: 10.4049/jimmunol.1103466. View

Quesenberry P, Aliotta J . Cellular phenotype switching and microvesicles. Adv Drug Deliv Rev. 2010; 62(12):1141-8. PMC: 2955803. DOI: 10.1016/j.addr.2010.06.001. View

Timmers L, Lim S, Hoefer I, Arslan F, Lai R, van Oorschot A . Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction. Stem Cell Res. 2011; 6(3):206-14. DOI: 10.1016/j.scr.2011.01.001. View

10.

Chivet M, Hemming F, Pernet-Gallay K, Fraboulet S, Sadoul R . Emerging role of neuronal exosomes in the central nervous system. Front Physiol. 2012; 3:145. PMC: 3361079. DOI: 10.3389/fphys.2012.00145. View

11.

Teng Y, Ren Y, Hu X, Mu J, Samykutty A, Zhuang X . MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression. Nat Commun. 2017; 8:14448. PMC: 5321731. DOI: 10.1038/ncomms14448. View

12.

Matsuzaka Y, Yashiro R . Regulation of Extracellular Vesicle-Mediated Immune Responses against Antigen-Specific Presentation. Vaccines (Basel). 2022; 10(10). PMC: 9607341. DOI: 10.3390/vaccines10101691. View

13.

Zhang J . Biomarkers of endothelial activation and dysfunction in cardiovascular diseases. Rev Cardiovasc Med. 2022; 23(2):73. DOI: 10.31083/j.rcm2302073. View

14.

Akbar N, Azzimato V, Choudhury R, Aouadi M . Extracellular vesicles in metabolic disease. Diabetologia. 2019; 62(12):2179-2187. PMC: 6861353. DOI: 10.1007/s00125-019-05014-5. View

15.

Pardo F, Villalobos-Labra R, Sobrevia B, Toledo F, Sobrevia L . Extracellular vesicles in obesity and diabetes mellitus. Mol Aspects Med. 2017; 60:81-91. DOI: 10.1016/j.mam.2017.11.010. View

16.

Soltani S, Mansouri K, Emami Aleagha M, Moasefi N, Yavari N, Shakouri S . Extracellular Vesicle Therapy for Type 1 Diabetes. Front Immunol. 2022; 13:865782. PMC: 9024141. DOI: 10.3389/fimmu.2022.865782. View

17.

Jafari N, Kolla M, Meshulam T, Shafran J, Qiu Y, Casey A . Adipocyte-derived exosomes may promote breast cancer progression in type 2 diabetes. Sci Signal. 2021; 14(710):eabj2807. PMC: 8765301. DOI: 10.1126/scisignal.abj2807. View

18.

Li G, Liu H, Ma C, Chen Y, Wang J, Yang Y . Exosomes are the novel players involved in the beneficial effects of exercise on type 2 diabetes. J Cell Physiol. 2019; 234(9):14896-14905. DOI: 10.1002/jcp.28319. View

19.

de Candia P, De Rosa V, Gigantino V, Botti G, Ceriello A, Matarese G . Immunometabolism of human autoimmune diseases: from metabolites to extracellular vesicles. FEBS Lett. 2017; 591(19):3119-3134. DOI: 10.1002/1873-3468.12733. View

20.

Samuelson I, Vidal-Puig A . Fed-EXosome: extracellular vesicles and cell-cell communication in metabolic regulation. Essays Biochem. 2018; 62(2):165-175. DOI: 10.1042/EBC20170087. View