Estrogen-ER-α Axis Induces PNPLA3 P.I148M Protein Variant to Promote Steatotic Liver Disease Susceptibility in Women

Overview

Journal Clin Transl Med

Publisher Wiley

Specialty General Medicine

Date 2024 Jan 15

PMID 38224202

Authors

Alessandro Cherubini

Elia Casirati

Serena Pelusi

Luca Valenti

Affiliations

Soon will be listed here.

Citing Articles

Estrogen-ER-α axis induces PNPLA3 p.I148M protein variant to promote steatotic liver disease susceptibility in women.

Cherubini A, Casirati E, Pelusi S, Valenti L Clin Transl Med. 2024; 14(1):e1524.

PMID: 38224202 PMC: 10788875. DOI: 10.1002/ctm2.1524.

References

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BasuRay S, Smagris E, Cohen J, Hobbs H . The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation. Hepatology. 2017; 66(4):1111-1124. PMC: 5605398. DOI: 10.1002/hep.29273. View

Cherubini A, Casirati E, Pelusi S, Valenti L . Estrogen-ER-α axis induces PNPLA3 p.I148M protein variant to promote steatotic liver disease susceptibility in women. Clin Transl Med. 2024; 14(1):e1524. PMC: 10788875. DOI: 10.1002/ctm2.1524. View

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10.

Cherubini A, Casirati E, Tomasi M, Valenti L . PNPLA3 as a therapeutic target for fatty liver disease: the evidence to date. Expert Opin Ther Targets. 2021; 25(12):1033-1043. DOI: 10.1080/14728222.2021.2018418. View

11.

Cherubini A, Ostadreza M, Jamialahmadi O, Pelusi S, Rrapaj E, Casirati E . Interaction between estrogen receptor-α and PNPLA3 p.I148M variant drives fatty liver disease susceptibility in women. Nat Med. 2023; 29(10):2643-2655. PMC: 10579099. DOI: 10.1038/s41591-023-02553-8. View