Similarities and Differences of Vascular Calcification in Diabetes and Chronic Kidney Disease

Overview

Journal Diabetes Metab Syndr Obes

Publisher Dove Medical Press

Specialty Endocrinology

Date 2024 Jan 15

PMID 38222032

Authors

Xiabo Wang

Zhongqun Wang

Jianqiang He

Affiliations

Soon will be listed here.

Abstract

Presently, the mechanism of occurrence and development of vascular calcification (VC) is not fully understood; a range of evidence suggests a positive association between diabetes mellitus (DM) and VC. Furthermore, the increasing burden of central vascular disease in patients with chronic kidney disease (CKD) may be due, at least in part, to VC. In this review, we will review recent advances in the mechanisms of VC in the context of CKD and diabetes. The study further unveiled that VC is induced through the stimulation of pro-inflammatory factors, which in turn impairs endothelial function and triggers similar mechanisms in both disease contexts. Notably, hyperglycemia was identified as the distinctive mechanism driving calcification in DM. Conversely, in CKD, calcification is facilitated by mechanisms including mineral metabolism imbalance and the presence of uremic toxins. Additionally, we underscore the significance of investigating vascular alterations and newly identified molecular pathways as potential avenues for therapeutic intervention.

Citing Articles

Elevated glucose levels increase vascular calcification risk by disrupting extracellular pyrophosphate metabolism.

Flores-Roco A, Lago B, Villa-Bellosta R Cardiovasc Diabetol. 2024; 23(1):405.

PMID: 39529124 PMC: 11555999. DOI: 10.1186/s12933-024-02502-w.

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