Epidemiological Research Advances in Vascular Calcification in Diabetes

Overview

Journal J Diabetes Res

Publisher Wiley

Specialty Endocrinology

Date 2021 Oct 11

PMID 34631895

Citations 11

Authors

Haipeng Yao

Zhen Sun

Guangyao Zang

Lili Zhang

Lina Hou

Chen Shao

Zhongqun Wang

Affiliations

Soon will be listed here.

Abstract

Vascular calcification is the transformation of arterial wall mesenchymal cells, particularly smooth muscle cells (SMCs), into osteoblast phenotypes by various pathological factors. Additionally, vascular transformation mediates the abnormal deposition of calcium salts in the vascular wall, such as intimal and media calcification. Various pathological types have been described, such as calcification and valve calcification. The incidence of vascular calcification in patients with diabetes is much higher than that in nondiabetic patients, representing a critical cause of cardiovascular events in patients with diabetes. Because basic research on the clinical transformation of vascular calcification has yet to be conducted, this study systematically expounds on the risk factors for vascular calcification, vascular bed differences, sex differences, ethnic differences, diagnosis, severity assessments, and treatments to facilitate the identification of a new entry point for basic research and subsequent clinical transformation regarding vascular calcification and corresponding clinical evaluation strategies.

Citing Articles

Role of abdominal aortic calcification score in predicting cardiovascular risk in the general population.

Ji Y, Lv N, Gu Y, Han X, Dang A Ir J Med Sci. 2025; .

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Danlian-Tongmai formula improves diabetic vascular calcification by regulating CCN3/NOTCH signal axis to inhibit inflammatory reaction.

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The Physiological Functions and Therapeutic Potential of Hypoxia-Inducible Factor-1α in Vascular Calcification.

Zhang Z, Wang D, Xu R, Li X, Wang Z, Zhang Y Biomolecules. 2025; 14(12.

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Elevated glucose levels increase vascular calcification risk by disrupting extracellular pyrophosphate metabolism.

Flores-Roco A, Lago B, Villa-Bellosta R Cardiovasc Diabetol. 2024; 23(1):405.

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: A possible target for vascular calcification.

Pan X, Song Y, Liang Y, Feng G, Wang Z Heliyon. 2024; 10(21):e39865.

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References

Hsu H, Culley N . Effects of dietary calcium on atherosclerosis, aortic calcification, and icterus in rabbits fed a supplemental cholesterol diet. Lipids Health Dis. 2006; 5:16. PMC: 1513571. DOI: 10.1186/1476-511X-5-16. View

Harper E, Forde H, Davenport C, Rochfort K, Smith D, Cummins P . Vascular calcification in type-2 diabetes and cardiovascular disease: Integrative roles for OPG, RANKL and TRAIL. Vascul Pharmacol. 2016; 82:30-40. DOI: 10.1016/j.vph.2016.02.003. View

Mirza R, Fang M, Weinheimer-Haus E, Ennis W, Koh T . Sustained inflammasome activity in macrophages impairs wound healing in type 2 diabetic humans and mice. Diabetes. 2013; 63(3):1103-14. PMC: 3931398. DOI: 10.2337/db13-0927. View

Salem S, Bruck H, Bahlmann F, Peter M, Passlick-Deetjen J, Kretschmer A . Relationship between magnesium and clinical biomarkers on inhibition of vascular calcification. Am J Nephrol. 2011; 35(1):31-9. DOI: 10.1159/000334742. View

Ma W, Sun X, Wang Y, Zhu Y, Han X, Liu N . Restoring mitochondrial biogenesis with metformin attenuates β-GP-induced phenotypic transformation of VSMCs into an osteogenic phenotype via inhibition of PDK4/oxidative stress-mediated apoptosis. Mol Cell Endocrinol. 2018; 479:39-53. DOI: 10.1016/j.mce.2018.08.012. View

Stefan N, Hennige A, Staiger H, Machann J, Schick F, Krober S . Alpha2-Heremans-Schmid glycoprotein/fetuin-A is associated with insulin resistance and fat accumulation in the liver in humans. Diabetes Care. 2006; 29(4):853-7. DOI: 10.2337/diacare.29.04.06.dc05-1938. View

Lavery L, Armstrong D, Wunderlich R, Mohler M, Wendel C, Lipsky B . Risk factors for foot infections in individuals with diabetes. Diabetes Care. 2006; 29(6):1288-93. DOI: 10.2337/dc05-2425. View

Villadsen P, Petersen S, Dey D, Zou L, Patel S, Naderi H . Coronary atherosclerotic plaque burden and composition by CT angiography in Caucasian and South Asian patients with stable chest pain. Eur Heart J Cardiovasc Imaging. 2016; 18(5):556-567. PMC: 5837200. DOI: 10.1093/ehjci/jew085. View

Allison M, Pavlinac P, Wright C . The differential associations between HDL, non-HDL and total cholesterols and atherosclerotic calcium deposits in multiple vascular beds. Atherosclerosis. 2006; 194(2):e87-94. DOI: 10.1016/j.atherosclerosis.2006.10.006. View

10.

Tang F, Chen S, Wu X, Wang T, Chen J, Li J . Hypercholesterolemia accelerates vascular calcification induced by excessive vitamin D via oxidative stress. Calcif Tissue Int. 2006; 79(5):326-39. DOI: 10.1007/s00223-006-0004-8. View

11.

Ong K, McClelland R, Rye K, Cheung B, Post W, Vaidya D . The relationship between insulin resistance and vascular calcification in coronary arteries, and the thoracic and abdominal aorta: the Multi-Ethnic Study of Atherosclerosis. Atherosclerosis. 2014; 236(2):257-62. PMC: 4170001. DOI: 10.1016/j.atherosclerosis.2014.07.015. View

12.

Hillis G, Welsh P, Chalmers J, Perkovic V, Chow C, Li Q . The relative and combined ability of high-sensitivity cardiac troponin T and N-terminal pro-B-type natriuretic peptide to predict cardiovascular events and death in patients with type 2 diabetes. Diabetes Care. 2013; 37(1):295-303. DOI: 10.2337/dc13-1165. View

13.

Volgman A, Palaniappan L, Aggarwal N, Gupta M, Khandelwal A, Krishnan A . Atherosclerotic Cardiovascular Disease in South Asians in the United States: Epidemiology, Risk Factors, and Treatments: A Scientific Statement From the American Heart Association. Circulation. 2018; 138(1):e1-e34. DOI: 10.1161/CIR.0000000000000580. View

14.

Kay A, Simpson C, Stewart Jr J . The Role of AGE/RAGE Signaling in Diabetes-Mediated Vascular Calcification. J Diabetes Res. 2016; 2016:6809703. PMC: 4980539. DOI: 10.1155/2016/6809703. View

15.

Yahagi K, Kolodgie F, Lutter C, Mori H, Romero M, Finn A . Pathology of Human Coronary and Carotid Artery Atherosclerosis and Vascular Calcification in Diabetes Mellitus. Arterioscler Thromb Vasc Biol. 2016; 37(2):191-204. PMC: 5269516. DOI: 10.1161/ATVBAHA.116.306256. View

16.

Tison G, Blaha M, Nasir K . Atherosclerosis imaging in multiple vascular beds--enough heterogeneity to improve risk prediction?. Atherosclerosis. 2010; 214(2):261-3. DOI: 10.1016/j.atherosclerosis.2010.10.014. View

17.

Walrand S, Guillet C, Boirie Y, Vasson M . In vivo evidences that insulin regulates human polymorphonuclear neutrophil functions. J Leukoc Biol. 2004; 76(6):1104-10. DOI: 10.1189/jlb.0104050. View

18.

Drueke T, Massy Z . Role of vitamin D in vascular calcification: bad guy or good guy?. Nephrol Dial Transplant. 2012; 27(5):1704-7. DOI: 10.1093/ndt/gfs046. View

19.

Alique M, Ruiz-Torres M, Bodega G, Noci M, Troyano N, Bohorquez L . Microvesicles from the plasma of elderly subjects and from senescent endothelial cells promote vascular calcification. Aging (Albany NY). 2017; 9(3):778-789. PMC: 5391231. DOI: 10.18632/aging.101191. View

20.

Allison M, Budoff M, Nasir K, Wong N, Detrano R, Kronmal R . Ethnic-specific risks for atherosclerotic calcification of the thoracic and abdominal aorta (from the Multi-Ethnic Study of Atherosclerosis). Am J Cardiol. 2009; 104(6):812-7. PMC: 2755558. DOI: 10.1016/j.amjcard.2009.05.004. View