D-pipecolic Acid Inhibits Ethanol Tolerance in Mice

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 1986 Dec 1

PMID 3822050

Citations 1

Authors

G Szabo

G L Kovacs

L Balaspiri

G Telegdy

Affiliations

Soon will be listed here.

Abstract

The effects of graded doses of D-pipecolic acid (0.005-5 micrograms/animals s.c.) on tolerance to the hypothermic effect of ethanol (4 g/kg i.p.) were investigated in mice. D-Pipecolic acid itself did not change the core temperature or the acute hypothermic response to a single dose of ethanol. Repeated D-pipecolic acid administration, however, blocked the development of tolerance to the hypothermic effect of ethanol. The development of tolerance could be observed in the control group. It is assumed that D-pipecolic acid is capable of counteracting the tolerance effect of ethanol.

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