Mesenchymal Stromal Cell Delivery Via Cardiopulmonary Bypass Provides Neuroprotection in a Juvenile Porcine Model

Overview

Journal JACC Basic Transl Sci

Date 2024 Jan 11

PMID 38205346

Authors

Kamil Sarkislali

Kei Kobayashi

Nemanja Saric

Takuya Maeda

Soichiro Henmi

Fahad A Somaa

Ankush Bansal

Shao Ching Tu

Camille Leonetti

Chao-Hsiung Hsu

Jingang Li

Pranav Vyas

Yuka Imamura Kawasawa

Tsang-Wei Tu

Paul C Wang

Patrick J Hanley

Kazue Hashimoto-Torii

Joseph A Frank

Richard A Jonas

Nobuyuki Ishibashi

Affiliations

Soon will be listed here.

Abstract

Oxidative/inflammatory stresses due to cardiopulmonary bypass (CPB) cause prolonged microglia activation and cortical dysmaturation, thereby contributing to neurodevelopmental impairments in children with congenital heart disease (CHD). This study found that delivery of mesenchymal stromal cells (MSCs) via CPB minimizes microglial activation and neuronal apoptosis, with subsequent improvement of cortical dysmaturation and behavioral alteration after neonatal cardiac surgery. Furthermore, transcriptomic analyses suggest that exosome-derived miRNAs may be the key drivers of suppressed apoptosis and STAT3-mediated microglial activation. Our findings demonstrate that MSC treatment during cardiac surgery has significant translational potential for improving cortical dysmaturation and neurological impairment in children with CHD.

Citing Articles

The role of microglia in Neuroinflammation associated with cardiopulmonary bypass.

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Establishing Optimal Control Cohorts for Phase 1 Trials: Retrospective Analysis of Clinical and Biological Outcomes in Neonates and Infants Undergoing Two-Ventricle Repair.

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Can Mesenchymal Stem Cell-Derived Therapeutics Protect the Developing Brain During Cardiac Surgery?.

Hansmann G JACC Basic Transl Sci. 2024; 8(12):1536-1538.

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