Association of Gene Polymorphisms with Kashin-Beck Disease Risk in the Chinese Han Population

Overview

Journal Open Med (Wars)

Specialty General Medicine

Date 2024 Jan 11

PMID 38205152

Authors

Na He

Aiwen Hong

Kun Zhao

Zhefan Zhang

Shengli Wang

Yaofei Jia

Affiliations

Soon will be listed here.

Abstract

Kashin-Beck disease (KBD) is an endemic osteochondropathy. A specific gene called SRY-box transcription factor 6 () is important for forming cartilage. This study aims to explore the potential correlation between single nucleotide polymorphisms (SNPs) and KBD risk for the first time. In the case-control study, 735 unrelated Chinese Han individuals were enrolled. The four mutation sites of the gene (rs4539287 G/A, rs3203295 C/A, rs7928675 C/A, and rs10832681 A/G) were screened and genotyped on the Agena MassARRAY platform. The correlation between SNPs and KBD risk was explored based on logistic regression analysis. The interaction between SNP and SNP was analyzed based on the multi-factor dimensionality reduction (MDR) method. Overall analysis revealed a remarkable correlation between rs7928675 and rs10832681 and the reduction of KBD risk ( < 0.05). Subgroup analyses further indicated that these two SNPs have a significant protective effect on KBD risk among participants aged ≤65 years, males, and non-smokers ( < 0.05). MDR displayed a marked interaction between rs3203295 and rs10832681. Our study revealed that rs7928675 and rs10832681 are markedly correlated with a reduced risk of KBD in the Chinese Han population, providing a new direction for the prevention, diagnosis, and treatment of KBD.

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