Bioactivities of Steroids and Sesquiterpenes from the Branches and Leaves of

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2024 Jan 11

PMID 38202622

Authors

Jingjing Dong

HanFei Liu

Huan Wang

Huayong Lou

Weidong Pan

Jinyu Li

Affiliations

Soon will be listed here.

Abstract

Five undescribed steroids and one sesquiterpene, named Aglaians A-F, along with sixteen known analogs, have been isolated from the branches and leaves of . Its structure was elucidated by IR, HRESIMS, 1D and 2D NMR, quantum-chemical calculations, electronic circular dichroism (ECD) calculations, and single-crystal X-ray diffraction analysis. The cytotoxic and antibacterial activities of six human tumor cell lines were evaluated (MDA-MB-231, MCF-7, Ln-cap, A549, HeLa, and HepG-2), and four strains of bacteria (, , , and ). The bioassay results indicated that compounds and exhibited moderate antitumor activity with IC values ranging from 16.72 to 36.14 μM. Furthermore, compounds - possess antibacterial activities against four bacteria with MIC values of 25-100 μM.

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PMID: 39135974 PMC: 11317792. DOI: 10.1039/d4ra04727c.

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