Short-Term Outcomes of XEN45 Standalone Versus Combined with Phacoemulsification in Open-Angle Glaucoma Patients: A Retrospective Study

Overview

Journal J Clin Med

Specialty General Medicine

Date 2024 Jan 11

PMID 38202164

Authors

Vittorio Pirani

Francesco Virgili

Vincenzo Ramovecchi

Affiliations

Soon will be listed here.

Abstract

The XEN45 is a minimally invasive glaucoma surgery device commonly used in clinical practice. This retrospective study included consecutive patients with open-angle glaucoma who underwent a XEN45 implant with mitomycin C, either alone or in combination with phacoemulsification, between June 2015 and March 2021. The primary end point was the mean change in intraocular pressure (IOP) from the baseline to month 6. A total of 677 eyes, 395 (58.3%) in the XEN alone group and 282 (41.7%) in the XEN+Phaco group, were included in this study. The preoperative IOP was significantly lowered from 28.7 ± 8.6 mmHg and 25.4 ± 6.9 mmHg to 13.5 ± 5.0 mmHg and 13.5 ± 4.1 mmHg at month 6 in the XEN solo and XEN+Phaco groups, respectively, with < 0.0001 each. The mean (95% confidence interval) number of ocular hypotensive medications was significantly reduced from 3.3 (3.2-3.4) to 0.2 (0.1-0.2) and from 3.1 (2.9-3.2) to 0.2 (0.1-0.2) in the XEN solo and XEN+Phaco groups, respectively, with < 0.0001 each. Needling was performed in 228 (33.7%) eyes. Conclusions: the XEN implant significantly reduces both IOP and the number of ocular hypotensive medications. IOP lowering was higher in the XEN solo group than in the XEN+Phaco one, although such a difference was only evident during the first month after surgery.

Citing Articles

No Changes in Keratometry Readings and Anterior Chamber Depth after XEN Gel Implantation in Patients with Glaucoma.

Tatti F, Tronci C, Lixi F, Demarinis G, Kuzmich S, Peiretti E J Clin Med. 2024; 13(9).

PMID: 38731065 PMC: 11084149. DOI: 10.3390/jcm13092537.

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