Nutritional Regulation of Microbiota-derived Metabolites: Implications for Immunity and Inflammation

Overview

Journal Immunity

Publisher Cell Press

Specialty Allergy & Immunology

Date 2024 Jan 10

PMID 38198849

Authors

Mohammad Arifuzzaman

Nicholas Collins

Chun-Jun Guo

David Artis

Affiliations

Soon will be listed here.

Abstract

Nutrition profoundly shapes immunity and inflammation across the lifespan of mammals, from pre- and post-natal periods to later life. Emerging insights into diet-microbiota interactions indicate that nutrition has a dominant influence on the composition-and metabolic output-of the intestinal microbiota, which in turn has major consequences for host immunity and inflammation. Here, we discuss recent findings that support the concept that dietary effects on microbiota-derived metabolites potently alter immune responses in health and disease. We discuss how specific dietary components and metabolites can be either pro-inflammatory or anti-inflammatory in a context- and tissue-dependent manner during infection, chronic inflammation, and cancer. Together, these studies emphasize the influence of diet-microbiota crosstalk on immune regulation that will have a significant impact on precision nutrition approaches and therapeutic interventions for managing inflammation, infection, and cancer immunotherapy.

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