Hair Growth-Promoting Effects of Rosehip ( L.) Seed Oil in C57BL/6 Mice

Overview

Journal Prev Nutr Food Sci

Date 2024 Jan 8

PMID 38188083

Authors

Van-Long Truong

Woo-Sik Jeong

Affiliations

Soon will be listed here.

Abstract

Rosehip ( L.) seeds, a by-product of the food processing industry, contain various bioactive compounds that have potential cosmetic and pharmacological applications. Rosehip seed oil (RHSO) has been shown to exert therapeutic effects in skin disorders, but its role in promoting hair growth remains unknown. In this study, we aimed to elucidate the hair growth-promoting activity of RHSO and the related mechanisms of action. The depleted dorsal skin of telogenic C57BL/6 mice was topically treated with RHSO for 21 days, and the extent of hair regrowth was assessed. The results indicated that RHSO stimulated hair growth by inducing the early transition of hair follicles from telogen to anagen phase. Histological analysis revealed significant increases in hair follicle density, hair bulb size, and skin thickness. RHSO treatment also upregulated the expression of hair growth-associated genes, including β-catenin, phospho-glycogen synthase kinase-3 beta, Sonic hedgehog, smoothened, cyclin D1, cyclin E, and insulin like growth factor 1. These findings suggest that RHSO stimulates hair growth and may show promise as a preventive and/or therapeutic agent for hair loss.

References

Belkhelladi M, Bougrine A . Rosehip extract and wound healing: A review. J Cosmet Dermatol. 2023; 23(1):62-67. DOI: 10.1111/jocd.15971. View

St-Jacques B, Dassule H, Karavanova I, Botchkarev V, Li J, Danielian P . Sonic hedgehog signaling is essential for hair development. Curr Biol. 1998; 8(19):1058-68. DOI: 10.1016/s0960-9822(98)70443-9. View

Harada N, Okajima K, Narimatsu N, Kurihara H, Nakagata N . Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans. Growth Horm IGF Res. 2008; 18(4):335-44. DOI: 10.1016/j.ghir.2008.01.005. View

Muller-Rover S, Handjiski B, van der Veen C, Eichmuller S, Foitzik K, McKay I . A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. J Invest Dermatol. 2001; 117(1):3-15. DOI: 10.1046/j.0022-202x.2001.01377.x. View

Houschyar K, Borrelli M, Tapking C, Popp D, Puladi B, Ooms M . Molecular Mechanisms of Hair Growth and Regeneration: Current Understanding and Novel Paradigms. Dermatology. 2020; 236(4):271-280. DOI: 10.1159/000506155. View

Huelsken J, Vogel R, Erdmann B, Cotsarelis G, Birchmeier W . beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell. 2001; 105(4):533-45. DOI: 10.1016/s0092-8674(01)00336-1. View

Marmol I, Sanchez-de-Diego C, Jimenez-Moreno N, Ancin-Azpilicueta C, Rodriguez-Yoldi M . Therapeutic Applications of Rose Hips from Different Rosa Species. Int J Mol Sci. 2017; 18(6). PMC: 5485961. DOI: 10.3390/ijms18061137. View

Lo Celso C, Prowse D, Watt F . Transient activation of beta-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours. Development. 2004; 131(8):1787-99. DOI: 10.1242/dev.01052. View

Sato N, Leopold P, Crystal R . Effect of adenovirus-mediated expression of Sonic hedgehog gene on hair regrowth in mice with chemotherapy-induced alopecia. J Natl Cancer Inst. 2001; 93(24):1858-64. DOI: 10.1093/jnci/93.24.1858. View

10.

Zhang Y, Han L, Chen S, Guan J, Qu F, Zhao Y . Hair growth promoting activity of cedrol isolated from the leaves of Platycladus orientalis. Biomed Pharmacother. 2016; 83:641-647. DOI: 10.1016/j.biopha.2016.07.022. View

11.

Akanda M, Kim H, Park M, Kim I, Ahn D, Tae H . Hair growth promoting activity of discarded biocomposite keratin extract. J Biomater Appl. 2017; 32(2):230-241. DOI: 10.1177/0885328217717076. View

12.

Schneider M, Schmidt-Ullrich R, Paus R . The hair follicle as a dynamic miniorgan. Curr Biol. 2009; 19(3):R132-42. DOI: 10.1016/j.cub.2008.12.005. View

13.

Al-Nuaimi Y, Baier G, Watson R, Chuong C, Paus R . The cycling hair follicle as an ideal systems biology research model. Exp Dermatol. 2010; 19(8):707-13. PMC: 4383261. DOI: 10.1111/j.1600-0625.2010.01114.x. View

14.

Choi Y, Zhang Y, Xu M, Yang Y, Ito M, Peng T . Distinct functions for Wnt/β-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis. Cell Stem Cell. 2013; 13(6):720-33. PMC: 3900235. DOI: 10.1016/j.stem.2013.10.003. View

15.

Lei Z, Cao Z, Yang Z, Ao M, Jin W, Yu L . Rosehip Oil Promotes Excisional Wound Healing by Accelerating the Phenotypic Transition of Macrophages. Planta Med. 2018; 85(7):563-569. DOI: 10.1055/a-0725-8456. View

16.

Kim E, Choi J, Park B, Lee B . Platycarya strobilacea S. et Z. Extract Has a High Antioxidant Capacity and Exhibits Hair Growth-promoting Effects in Male C57BL/6 Mice. Prev Nutr Food Sci. 2014; 19(3):136-44. PMC: 4195618. DOI: 10.3746/pnf.2014.19.3.136. View

17.

Oro A, Higgins K . Hair cycle regulation of Hedgehog signal reception. Dev Biol. 2003; 255(2):238-48. DOI: 10.1016/s0012-1606(02)00042-8. View

18.

Phetcharat L, Wongsuphasawat K, Winther K . The effectiveness of a standardized rose hip powder, containing seeds and shells of Rosa canina, on cell longevity, skin wrinkles, moisture, and elasticity. Clin Interv Aging. 2015; 10:1849-56. PMC: 4655903. DOI: 10.2147/CIA.S90092. View

19.

Truong V, Jeong W . Hair Growth-Promoting Mechanisms of Red Ginseng Extract through Stimulating Dermal Papilla Cell Proliferation and Enhancing Skin Health. Prev Nutr Food Sci. 2021; 26(3):275-284. PMC: 8531430. DOI: 10.3746/pnf.2021.26.3.275. View

20.

Millar S, Willert K, Salinas P, Roelink H, Nusse R, Sussman D . WNT signaling in the control of hair growth and structure. Dev Biol. 1999; 207(1):133-49. DOI: 10.1006/dbio.1998.9140. View