Flavonoids As Dual-target Inhibitors Against α-glucosidase and α-amylase: a Systematic Review of in Vitro Studies

Overview

Journal Nat Prod Bioprospect

Publisher Springer

Specialty Biology

Date 2024 Jan 7

PMID 38185713

Authors

Thua-Phong Lam

Ngoc-Vi Nguyen Tran

Long-Hung Dinh Pham

Nghia Vo-Trong Lai

Bao-Tran Ngoc Dang

Ngoc-Lam Nguyen Truong

Song-Ky Nguyen-Vo

Thuy-Linh Hoang

Tan Thanh Mai

Thanh-Dao Tran

Affiliations

Soon will be listed here.

Abstract

Diabetes mellitus remains a major global health issue, and great attention is directed at natural therapeutics. This systematic review aimed to assess the potential of flavonoids as antidiabetic agents by investigating their inhibitory effects on α-glucosidase and α-amylase, two key enzymes involved in starch digestion. Six scientific databases (PubMed, Virtual Health Library, EMBASE, SCOPUS, Web of Science, and WHO Global Index Medicus) were searched until August 21, 2022, for in vitro studies reporting IC values of purified flavonoids on α-amylase and α-glucosidase, along with corresponding data for acarbose as a positive control. A total of 339 eligible articles were analyzed, resulting in the retrieval of 1643 flavonoid structures. These structures were rigorously standardized and curated, yielding 974 unique compounds, among which 177 flavonoids exhibited inhibition of both α-glucosidase and α-amylase are presented. Quality assessment utilizing a modified CONSORT checklist and structure-activity relationship (SAR) analysis were performed, revealing crucial features for the simultaneous inhibition of flavonoids against both enzymes. Moreover, the review also addressed several limitations in the current research landscape and proposed potential solutions. The curated datasets are available online at https://github.com/MedChemUMP/FDIGA .

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