Alpha 2.0
Login Register
» Articles » PMID: 24125526

Flavonoids with α-glucosidase Inhibitory Activities and Their Contents in the Leaves of Morus Atropurpurea

Overview
Journal Chin Med
Publisher Biomed Central
Specialty Biomedical Engineering
Date 2013 Oct 16
PMID 24125526
Citations 25
Authors
Hin-Chu Hong
Song-Lin Li
Xiao-Qi Zhang
Wen-Cai Ye
Qing-Wen Zhang
Affiliations
Soon will be listed here.
Abstract

Background: This study aims to isolate the α-glucosidase inhibitory compounds from mulberry leaves (Morus atropurpurea Roxb., Moraceae) and to develop an analytical method for quantification of the compounds.

Methods: Four flavonoids, rutin (1), isoquercetin (2), kaempferol-3-O-rutinoside (3) and astragalin (4), were isolated by column chromatography from mulberry leaf water extracts (MWE). The α-glucosidase inhibitory activities of MWE and the four isolated compounds were evaluated by a microplate-based in vitro assay. The content of the isolated flavonoids in M. atropurpurea leaves purchased from different local herbal stores or collected in different locations was determined by high performance liquid chromatography.

Results: The four flavonoids (1-4) showed α-glucosidase inhibitory activities, with rutin (1) and astragalin (4) showing high α-glucosidase inhibitory activities (IC50 values of 13.19 ± 1.10 and 15.82 ± 1.11 μM, respectively). The total contents of the four flavonoids were different among eight samples examined, ranging from 4.34 mg/g to 0.53 mg/g.

Conclusions: The four flavonoids in M. atropurpurea leaves could inhibit α-glucosidase activity.

Citing Articles

Dynamics of flavonoid metabolites in coconut water based on metabolomics perspective.

Hou M, John Martin J, Song Y, Wang Q, Cao H, Li W Front Plant Sci. 2024; 15:1468858.

PMID: 39435019 PMC: 11491327. DOI: 10.3389/fpls.2024.1468858.

Biosynthesis and Pharmacological Activities of the Bioactive Compounds of White Mulberry (): Current Paradigms and Future Challenges.

Fatima M, Dar M, Dhanavade M, Abbas S, Bukhari M, Arsalan A Biology (Basel). 2024; 13(7).

PMID: 39056699 PMC: 11274221. DOI: 10.3390/biology13070506.

Antimicrobial and alpha-glucosidase inhibitory flavonoid glycosides from the plant : and approaches.

Mai T, Minh P, Phat N, Duong T, Minh An T, Dang V RSC Adv. 2024; 14(13):9326-9338.

PMID: 38505391 PMC: 10950057. DOI: 10.1039/d4ra00666f.

Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies.

Lam T, Tran N, Pham L, Lai N, Dang B, Truong N Nat Prod Bioprospect. 2024; 14(1):4.

PMID: 38185713 PMC: 10772047. DOI: 10.1007/s13659-023-00424-w.

A Basic Study of the Effects of Mulberry Leaf Administration to Healthy C57BL/6 Mice on Gut Microbiota and Metabolites.

Gan L, Inamura Y, Shimizu Y, Yokoi Y, Ohnishi Y, Song Z Metabolites. 2023; 13(9).

PMID: 37755283 PMC: 10535692. DOI: 10.3390/metabo13091003.

References
1.
Yatsunami K, Ichida M, Onodera S . The relationship between 1-deoxynojirimycin content and alpha-glucosidase inhibitory activity in leaves of 276 mulberry cultivars (Morus spp.) in Kyoto, Japan. J Nat Med. 2008; 62(1):63-6. DOI: 10.1007/s11418-007-0185-0. View
2.
Naowaboot J, Pannangpetch P, Kukongviriyapan V, Kongyingyoes B, Kukongviriyapan U . Antihyperglycemic, antioxidant and antiglycation activities of mulberry leaf extract in streptozotocin-induced chronic diabetic rats. Plant Foods Hum Nutr. 2009; 64(2):116-21. DOI: 10.1007/s11130-009-0112-5. View
3.
Kwon H, Chung J, Kim J, Kwon O . Comparison of 1-deoxynojirimycin and aqueous mulberry leaf extract with emphasis on postprandial hypoglycemic effects: in vivo and in vitro studies. J Agric Food Chem. 2011; 59(7):3014-9. DOI: 10.1021/jf103463f. View
4.
Kim G, Kwon Y, Jang H . Mulberry leaf extract reduces postprandial hyperglycemia with few side effects by inhibiting α-glucosidase in normal rats. J Med Food. 2011; 14(7-8):712-7. DOI: 10.1089/jmf.2010.1368. View