Association of Phase Angle with Sarcopenia and Muscle Function in Patients with COPD: a Case-control Study

Overview

Journal BMC Pulm Med

Publisher Biomed Central

Specialty Pulmonary Medicine

Date 2024 Jan 6

PMID 38184558

Authors

Neda Valisoltani

Hamed Mohammadi

Rasoul Aliannejad

Fatemeh Naeini

Asma Rajabi Harsini

Erfan Sadeghi

Pouya Mirzaee

Hossein Imani

Affiliations

Soon will be listed here.

Abstract

Background And Aims: The predictive value of phase angle for sarcopenia diagnosis has been discussed for years. The present investigation was conducted to determine the association between phase angle and sarcopenia in patients with COPD.

Methods: In this case-control study, 222 smoker men were divided into healthy and COPD groups. COPD was diagnosed by a pulmonologist through spirometry. Anthropometric indices, phase angle, muscle function, sarcopenia, and dietary intake were assessed.

Results: A significant inverse association was observed between phase angle and sarcopenia after adjustment for age and energy intake (OR: 0.31, 95% CI 0.18-0.52) and after adjustment for BMI (OR: 0.31, 95% CI 0.18-0.52). A significant decrease was detected in anthropometric indices and indicators of sarcopenia and muscle function in COPD cases compared to the healthy controls.

Conclusions: Although further studies are suggested, phase angle might be considered an indicator of sarcopenia and muscle function in COPD patients.

Citing Articles

Prevalence and associated body composition factors of sarcopenia in community-dwelling older adults.

Wang B, Nong C, Zhang J, Deng L, Li W, Zhang X Eur J Med Res. 2024; 29(1):598.

PMID: 39696545 PMC: 11657734. DOI: 10.1186/s40001-024-02185-9.

References

Santaniello M, de Blasio F, Mazzarella G, Bianco A, Lionetti L, Franssen F . Raw BIA variables are predictors of muscle strength in patients with chronic obstructive pulmonary disease. Eur J Clin Nutr. 2017; 71(11):1336-1340. DOI: 10.1038/ejcn.2017.147. View

Ji W, Liu X, Zheng K, Yang H, Cui J, Li W . Correlation of phase angle with sarcopenia and its diagnostic value in elderly men with cancer. Nutrition. 2021; 84:111110. DOI: 10.1016/j.nut.2020.111110. View

Viegi G, Pistelli F, Sherrill D, Maio S, Baldacci S, Carrozzi L . Definition, epidemiology and natural history of COPD. Eur Respir J. 2007; 30(5):993-1013. DOI: 10.1183/09031936.00082507. View

Holland A, Spruit M, Singh S . How to carry out a field walking test in chronic respiratory disease. Breathe (Sheff). 2015; 11(2):128-39. PMC: 4487379. DOI: 10.1183/20734735.021314. View

Zanella P, Avila C, Chaves F, Gazzana M, Cortozi Berton D, Knorst M . Phase Angle Evaluation of Lung Disease Patients and Its Relationship with Nutritional and Functional Parameters. J Am Coll Nutr. 2020; 40(6):529-534. DOI: 10.1080/07315724.2020.1801535. View

Devereux G . ABC of chronic obstructive pulmonary disease. Definition, epidemiology, and risk factors. BMJ. 2006; 332(7550):1142-4. PMC: 1459603. DOI: 10.1136/bmj.332.7550.1142. View

Ntritsos G, Franek J, Belbasis L, Christou M, Markozannes G, Altman P . Gender-specific estimates of COPD prevalence: a systematic review and meta-analysis. Int J Chron Obstruct Pulmon Dis. 2018; 13:1507-1514. PMC: 5953270. DOI: 10.2147/COPD.S146390. View

Esmaillzadeh A, Mirmiran P, Azizi F . Whole-grain intake and the prevalence of hypertriglyceridemic waist phenotype in Tehranian adults. Am J Clin Nutr. 2005; 81(1):55-63. DOI: 10.1093/ajcn/81.1.55. View

de Blasio F, Di Gregorio A, Blasio F, Bianco A, Bellofiore B, Scalfi L . Malnutrition and sarcopenia assessment in patients with chronic obstructive pulmonary disease according to international diagnostic criteria, and evaluation of raw BIA variables. Respir Med. 2018; 134:1-5. DOI: 10.1016/j.rmed.2017.11.006. View

10.

Kilic M, Kizilarslanoglu M, Arik G, Bolayir B, Kara O, Varan H . Association of Bioelectrical Impedance Analysis-Derived Phase Angle and Sarcopenia in Older Adults. Nutr Clin Pract. 2016; 32(1):103-109. DOI: 10.1177/0884533616664503. View

11.

Wouters E, Creutzberg E, Schols A . Systemic effects in COPD. Chest. 2002; 121(5 Suppl):127S-130S. DOI: 10.1378/chest.121.5_suppl.127s. View

12.

Mundstock E, Amaral M, Baptista R, Sarria E, Dos Santos R, Filho A . Association between phase angle from bioelectrical impedance analysis and level of physical activity: Systematic review and meta-analysis. Clin Nutr. 2018; 38(4):1504-1510. DOI: 10.1016/j.clnu.2018.08.031. View

13.

de Blasio F, Blasio F, Berlingieri G, Bianco A, La Greca M, Franssen F . Evaluation of body composition in COPD patients using multifrequency bioelectrical impedance analysis. Int J Chron Obstruct Pulmon Dis. 2016; 11:2419-2426. PMC: 5053371. DOI: 10.2147/COPD.S110364. View

14.

Shim J, Oh K, Kim H . Dietary assessment methods in epidemiologic studies. Epidemiol Health. 2014; 36:e2014009. PMC: 4154347. DOI: 10.4178/epih/e2014009. View

15.

Jones S, Kon S, Canavan J, Patel M, Clark A, M Nolan C . The five-repetition sit-to-stand test as a functional outcome measure in COPD. Thorax. 2013; 68(11):1015-20. DOI: 10.1136/thoraxjnl-2013-203576. View

16.

Do J, Kim A, Kang S . Association Between Phase Angle and Sarcopenia in Patients Undergoing Peritoneal Dialysis. Front Nutr. 2021; 8:742081. PMC: 8497817. DOI: 10.3389/fnut.2021.742081. View

17.

Lukaski H, Kyle U, Kondrup J . Assessment of adult malnutrition and prognosis with bioelectrical impedance analysis: phase angle and impedance ratio. Curr Opin Clin Nutr Metab Care. 2017; 20(5):330-339. DOI: 10.1097/MCO.0000000000000387. View

18.

Norman K, Wirth R, Neubauer M, Eckardt R, Stobaus N . The bioimpedance phase angle predicts low muscle strength, impaired quality of life, and increased mortality in old patients with cancer. J Am Med Dir Assoc. 2014; 16(2):173.e17-22. DOI: 10.1016/j.jamda.2014.10.024. View

19.

Beberashvili I, Azar A, Sinuani I, Shapiro G, Feldman L, Stav K . Bioimpedance phase angle predicts muscle function, quality of life and clinical outcome in maintenance hemodialysis patients. Eur J Clin Nutr. 2014; 68(6):683-9. DOI: 10.1038/ejcn.2014.67. View

20.

de Blasio F, Scalfi L, Di Gregorio A, Alicante P, Bianco A, Tantucci C . Raw Bioelectrical Impedance Analysis Variables Are Independent Predictors of Early All-Cause Mortality in Patients With COPD. Chest. 2019; 155(6):1148-1157. DOI: 10.1016/j.chest.2019.01.001. View