Plasma Levels of Neurogenic Inflammation Related Neuropeptides in Pediatric Patients with Community-acquired Pneumonia and Their Potential Diagnostic Value in Distinguishing Viral and Bacterial Pneumonia

Overview

Journal Eur J Pediatr

Specialty Pediatrics

Date 2024 Jan 6

PMID 38183438

Authors

Mervan Bekdas

Bilgi Saygi

Yasemin Baranoglu Kilinc

Erkan Kilinc

Affiliations

Soon will be listed here.

Abstract

Conclusions: Our findings suggest that these neuropeptides may be implicated in pediatric CAP. CGRP, SP and NPY together may be a promising candidate in distinguishing viral and bacterial/mixed pneumonia, however, for this, further studies are needed.

What Is Known: • Neurogenic inflammation contributes to the development and progression of respiratory inflammatory diseases such as chronic obstructive pulmonary disease and bronchial asthma.

What Is New: • Plasma levels of neurogenic inflammation related neuropeptides calcitonin gene-related peptide, substance P, vasoactive intestinal peptide and neuropeptide Y are changed in pediatric community-acquired pneumonia. Calcitonin gene-related peptide, substance P and neuropeptide Y are promising candidates in distinguishing viral and bacterial/mixed pneumonia.

Citing Articles

Diagnostic value of ultrasound for community-acquired pneumonia in children and its correlation with serum PCT level and PCIS.

Liu Q, Feng Z, Huang K, Yang Z, Xu L, Shen Y Medicine (Baltimore). 2024; 103(43):e39590.

PMID: 39470492 PMC: 11521007. DOI: 10.1097/MD.0000000000039590.

References

Handy L, Bryan M, Gerber J, Zaoutis T, Feemster K . Variability in Antibiotic Prescribing for Community-Acquired Pneumonia. Pediatrics. 2017; 139(4). PMC: 5369668. DOI: 10.1542/peds.2016-2331. View

Dellit T, Owens R, McGowan Jr J, Gerding D, Weinstein R, Burke J . Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship. Clin Infect Dis. 2006; 44(2):159-77. DOI: 10.1086/510393. View

Camp B, Stegemann-Koniszewski S, Schreiber J . Infection-Associated Mechanisms of Neuro-Inflammation and Neuro-Immune Crosstalk in Chronic Respiratory Diseases. Int J Mol Sci. 2021; 22(11). PMC: 8197882. DOI: 10.3390/ijms22115699. View

Groneberg D, Quarcoo D, Frossard N, Fischer A . Neurogenic mechanisms in bronchial inflammatory diseases. Allergy. 2004; 59(11):1139-52. DOI: 10.1111/j.1398-9995.2004.00665.x. View

Lagomarsino V, Kostic A, Chiu I . Mechanisms of microbial-neuronal interactions in pain and nociception. Neurobiol Pain. 2021; 9:100056. PMC: 7772816. DOI: 10.1016/j.ynpai.2020.100056. View

Chiu I, Heesters B, Ghasemlou N, von Hehn C, Zhao F, Tran J . Bacteria activate sensory neurons that modulate pain and inflammation. Nature. 2013; 501(7465):52-7. PMC: 3773968. DOI: 10.1038/nature12479. View

Barnes P . Neurogenic inflammation in the airways. Respir Physiol. 2001; 125(1-2):145-54. DOI: 10.1016/s0034-5687(00)00210-3. View

Liu Y, Zhang Y, Xu Q, Qiu Y, Lu Q, Wang T . Infection and co-infection patterns of community-acquired pneumonia in patients of different ages in China from 2009 to 2020: a national surveillance study. Lancet Microbe. 2023; 4(5):e330-e339. DOI: 10.1016/S2666-5247(23)00031-9. View

Farida H, Triasih R, Lokida D, Mardian Y, Salim G, Wulan W . Epidemiologic, clinical, and serum markers may improve discrimination between bacterial and viral etiologies of childhood pneumonia. Front Med (Lausanne). 2023; 10:1140100. PMC: 10233046. DOI: 10.3389/fmed.2023.1140100. View

10.

Thomas J, Pociute A, Kevalas R, Malinauskas M, Jankauskaite L . Blood biomarkers differentiating viral versus bacterial pneumonia aetiology: a literature review. Ital J Pediatr. 2020; 46(1):4. PMC: 6953310. DOI: 10.1186/s13052-020-0770-3. View

11.

Carlton H, Savovic J, Dawson S, Mitchelmore P, Elwenspoek M . Novel point-of-care biomarker combination tests to differentiate acute bacterial from viral respiratory tract infections to guide antibiotic prescribing: a systematic review. Clin Microbiol Infect. 2021; 27(8):1096-1108. DOI: 10.1016/j.cmi.2021.05.018. View

12.

Ingram P, Inglis T, Moxon D, Speers D . Procalcitonin and C-reactive protein in severe 2009 H1N1 influenza infection. Intensive Care Med. 2010; 36(3):528-32. PMC: 7080172. DOI: 10.1007/s00134-009-1746-3. View

13.

Kruger S, Ewig S, Papassotiriou J, Kunde J, Marre R, von Baum H . Inflammatory parameters predict etiologic patterns but do not allow for individual prediction of etiology in patients with CAP: results from the German competence network CAPNETZ. Respir Res. 2009; 10:65. PMC: 2714042. DOI: 10.1186/1465-9921-10-65. View

14.

Talbot S, Abdulnour R, Burkett P, Lee S, Cronin S, Pascal M . Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation. Neuron. 2015; 87(2):341-54. PMC: 4506220. DOI: 10.1016/j.neuron.2015.06.007. View

15.

Joyce C, Fiscus R, Wang X, Dries D, Morris R, Prinz R . Calcitonin gene-related peptide levels are elevated in patients with sepsis. Surgery. 1990; 108(6):1097-101. View

16.

Xu H, Zhao M, Wang X . [Changes of calcitonin gene-related peptide content in induced sputum from patients with COPD and asthma]. Zhonghua Jie He He Hu Xi Za Zhi. 2002; 22(9):558-61. View

17.

Gu X, Karp P, Brody S, Pierce R, Welsh M, Holtzman M . Chemosensory functions for pulmonary neuroendocrine cells. Am J Respir Cell Mol Biol. 2013; 50(3):637-46. PMC: 4068934. DOI: 10.1165/rcmb.2013-0199OC. View

18.

Groneberg D, Springer J, Fischer A . Vasoactive intestinal polypeptide as mediator of asthma. Pulm Pharmacol Ther. 2001; 14(5):391-401. DOI: 10.1006/pupt.2001.0306. View

19.

Mandal J, Roth M, Costa L, Boeck L, Rakic J, Scherr A . Vasoactive Intestinal Peptide for Diagnosing Exacerbation in Chronic Obstructive Pulmonary Disease. Respiration. 2015; 90(5):357-68. DOI: 10.1159/000439228. View

20.

OConnor T, OConnell J, OBrien D, Goode T, Bredin C, Shanahan F . The role of substance P in inflammatory disease. J Cell Physiol. 2004; 201(2):167-80. DOI: 10.1002/jcp.20061. View