Vasoactive Intestinal Polypeptide As Mediator of Asthma

Overview

Journal Pulm Pharmacol Ther

Specialty Pulmonary Medicine

Date 2001 Oct 18

PMID 11603952

Citations 23

Authors

D A Groneberg

J Springer

A Fischer

Affiliations

Soon will be listed here.

Abstract

Vasoactive intestinal polypeptide (VIP) is one of the most abundant, biologically active peptides found in the human lung. VIP is a likely neurotransmitter or neuromodulator of the inhibitory non-adrenergic non-cholinergic airway nervous system and influences many aspects of pulmonary biology. In human airways VIP-immunoreactive nerve fibres are present in the tracheobronchial airway smooth muscle layer, the walls of pulmonary and bronchial vessels and around submucosal glands. Next to its prominent bronchodilatory effects, VIP potently relaxes pulmonary vessels. The precise role of VIP in the pathogenesis of asthma is still uncertain. Although a therapy using the strong bronchodilatory effects of VIP would offer potential benefits, the rapid inactivation of the peptide by airway peptidases has prevented effective VIP-based drugs so far and non-peptide VIP-agonists did not reach clinical use.

Citing Articles

Eosinophils as drivers of bacterial immunomodulation and persistence.

Parrish K, Gestal M Infect Immun. 2024; 92(9):e0017524.

PMID: 39007622 PMC: 11385729. DOI: 10.1128/iai.00175-24.

An organism-wide atlas of hormonal signaling based on the mouse lemur single-cell transcriptome.

Liu S, Ezran C, Wang M, Li Z, Awayan K, Long J Nat Commun. 2024; 15(1):2188.

PMID: 38467625 PMC: 10928088. DOI: 10.1038/s41467-024-46070-9.

Plasma levels of neurogenic inflammation related neuropeptides in pediatric patients with community-acquired pneumonia and their potential diagnostic value in distinguishing viral and bacterial pneumonia.

Bekdas M, Saygi B, Baranoglu Kilinc Y, Kilinc E Eur J Pediatr. 2024; 183(4):1619-1627.

PMID: 38183438 PMC: 11001734. DOI: 10.1007/s00431-023-05417-y.

spp. utilize the type 3 secretion system to manipulate the VIP/VPAC2 signaling and promote colonization and persistence of the three classical in the lower respiratory tract.

First N, Pedreira-Lopez J, San-Silvestre M, Parrish K, Lu X, Gestal M Front Cell Infect Microbiol. 2023; 13:1111502.

PMID: 37065208 PMC: 10090565. DOI: 10.3389/fcimb.2023.1111502.

Regulatory Peptides in Asthma.

Kaczynska K, Zajac D, Wojciechowski P, Jampolska M Int J Mol Sci. 2021; 22(24).

PMID: 34948451 PMC: 8707337. DOI: 10.3390/ijms222413656.