Schistosome Infection Impacts Hematopoiesis

Overview

Journal J Immunol

Specialty Allergy & Immunology

Date 2024 Jan 3

PMID 38169327

Authors

Tobias Wijshake

Joseph Rose 3rd

Jipeng Wang

Jacob Zielke

Madeleine Marlar-Pavey

Weina Chen

James J Collins 3rd

Michalis Agathocleous

Affiliations

Soon will be listed here.

Abstract

Helminth infections are common in animals. However, the impact of a helminth infection on the function of hematopoietic stem cells (HSCs) and other hematopoietic cells has not been comprehensively defined. In this article, we describe the hematopoietic response to infection of mice with Schistosoma mansoni, a parasitic flatworm that causes schistosomiasis. We analyzed the frequency or number of hematopoietic cell types in the bone marrow, spleen, liver, thymus, and blood and observed multiple hematopoietic changes caused by infection. Schistosome infection impaired bone marrow HSC function after serial transplantation. Functional HSCs were present in the infected liver. Infection blocked bone marrow erythropoiesis and augmented spleen erythropoiesis, observations consistent with the anemia and splenomegaly prevalent in schistosomiasis patients. This work defines the hematopoietic response to schistosomiasis, a debilitating disease afflicting more than 200 million people, and identifies impairments in HSC function and erythropoiesis.

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