What is Known About the Effects of Vitamin D in Neuropsychiatric Lupus?

Overview

Journal Adv Rheumatol

Publisher Biomed Central

Specialty Rheumatology

Date 2024 Jan 3

PMID 38167239

Authors

Thais Evelyn Karnopp

Vinicius da Silva Freitas

Andressa Leite Di Domenico

Gustavo Flores Chapacais

Natalia Garcia Dos Santos

Eduarda Correa Freitas

Andrese Aline Gasparin

Odirlei Andre Monticielo

Affiliations

Soon will be listed here.

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect several organs and systems. The central and/or peripheral nervous system can suffer from complications known as neuropsychiatric lupus (NPSLE). Studies have associated the manifestations of SLE or NPSLE with vitamin D deficiency. It has been shown that hypovitaminosis D can lead to cognition deficits and cerebral hypoperfusion in patients with NPSLE. In this review article, we will address the main features related to vitamin D supplementation or serum vitamin D levels with neuropsychiatric manifestations, either in patients or in animal models of NPSLE.

References

Fujieda Y . Diversity of neuropsychiatric manifestations in systemic lupus erythematosus. Immunol Med. 2020; 43(4):135-141. DOI: 10.1080/25785826.2020.1770947. View

Carrion-Barbera I, Salman-Monte T, Vilchez-Oya F, Monfort J . Neuropsychiatric involvement in systemic lupus erythematosus: A review. Autoimmun Rev. 2021; 20(4):102780. DOI: 10.1016/j.autrev.2021.102780. View

Karnopp T, Chapacais G, Freitas E, Monticielo O . Lupus animal models and neuropsychiatric implications. Clin Rheumatol. 2020; 40(7):2535-2545. DOI: 10.1007/s10067-020-05493-7. View

Yap K, Morand E . Vitamin D and systemic lupus erythematosus: continued evolution. Int J Rheum Dis. 2014; 18(2):242-9. DOI: 10.1111/1756-185X.12489. View

Jeffery L, Raza K, Hewison M . Vitamin D in rheumatoid arthritis-towards clinical application. Nat Rev Rheumatol. 2015; 12(4):201-10. DOI: 10.1038/nrrheum.2015.140. View

Mathieu C . Vitamin D and diabetes: Where do we stand?. Diabetes Res Clin Pract. 2015; 108(2):201-9. DOI: 10.1016/j.diabres.2015.01.036. View

Shoenfeld N, Amital H, Shoenfeld Y . The effect of melanism and vitamin D synthesis on the incidence of autoimmune disease. Nat Clin Pract Rheumatol. 2009; 5(2):99-105. DOI: 10.1038/ncprheum0989. View

Kamen D . Vitamin D in lupus - new kid on the block?. Bull NYU Hosp Jt Dis. 2010; 68(3):218-22. PMC: 4185297. View

Aranow C . Vitamin D and the immune system. J Investig Med. 2011; 59(6):881-6. PMC: 3166406. DOI: 10.2310/JIM.0b013e31821b8755. View

10.

Yap K, Northcott M, Hoi A, Morand E, Nikpour M . Association of low vitamin D with high disease activity in an Australian systemic lupus erythematosus cohort. Lupus Sci Med. 2015; 2(1):e000064. PMC: 4395813. DOI: 10.1136/lupus-2014-000064. View

11.

Manca E . Autoantibodies in Neuropsychiatric Systemic Lupus Erythematosus (NPSLE): Can They Be Used as Biomarkers for the Differential Diagnosis of This Disease?. Clin Rev Allergy Immunol. 2021; 63(2):194-209. PMC: 9464150. DOI: 10.1007/s12016-021-08865-2. View

12.

Govoni M, Bortoluzzi A, Padovan M, Silvagni E, Borrelli M, Donelli F . The diagnosis and clinical management of the neuropsychiatric manifestations of lupus. J Autoimmun. 2016; 74:41-72. DOI: 10.1016/j.jaut.2016.06.013. View

13.

Cohen D, Rijnink E, Nabuurs R, Steup-Beekman G, Versluis M, Emmer B . Brain histopathology in patients with systemic lupus erythematosus: identification of lesions associated with clinical neuropsychiatric lupus syndromes and the role of complement. Rheumatology (Oxford). 2016; 56(1):77-86. DOI: 10.1093/rheumatology/kew341. View

14.

Thirunavukkarasu B, Gupta K, Nada R, Rathi M, Dhir V, Ahuja C . Neuropathological spectrum in systemic lupus erythematosus: A single institute autopsy experience. J Neuroimmunol. 2021; 353:577518. DOI: 10.1016/j.jneuroim.2021.577518. View

15.

Liu Y, Tu Z, Zhang X, Du K, Xie Z, Lin Z . Pathogenesis and treatment of neuropsychiatric systemic lupus erythematosus: A review. Front Cell Dev Biol. 2022; 10:998328. PMC: 9484581. DOI: 10.3389/fcell.2022.998328. View

16.

Yun Y, Wang X, Xu J, Jin C, Chen J, Wang X . Pristane induced lupus mice as a model for neuropsychiatric lupus (NPSLE). Behav Brain Funct. 2023; 19(1):3. PMC: 9921421. DOI: 10.1186/s12993-023-00205-y. View

17.

Jeltsch-David H, Muller S . Neuropsychiatric systemic lupus erythematosus: pathogenesis and biomarkers. Nat Rev Neurol. 2014; 10(10):579-96. DOI: 10.1038/nrneurol.2014.148. View

18.

Aringer M, Costenbader K, Daikh D, Brinks R, Mosca M, Ramsey-Goldman R . 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus. Ann Rheum Dis. 2019; 78(9):1151-1159. DOI: 10.1136/annrheumdis-2018-214819. View

19.

Ainiala H, Hietaharju A, Loukkola J, Peltola J, Korpela M, Metsanoja R . Validity of the new American College of Rheumatology criteria for neuropsychiatric lupus syndromes: a population-based evaluation. Arthritis Rheum. 2001; 45(5):419-23. DOI: 10.1002/1529-0131(200110)45:5<419::aid-art360>3.0.co;2-x. View

20.

Meszaros Z, Perl A, Faraone S . Psychiatric symptoms in systemic lupus erythematosus: a systematic review. J Clin Psychiatry. 2012; 73(7):993-1001. PMC: 9903299. DOI: 10.4088/JCP.11r07425. View