The Effect of Melanism and Vitamin D Synthesis on the Incidence of Autoimmune Disease

Overview

Journal Nat Clin Pract Rheumatol

Specialty Rheumatology

Date 2009 Feb 3

PMID 19182816

Citations 48

Authors

Netta Shoenfeld

Howard Amital

Yehuda Shoenfeld

Affiliations

Soon will be listed here.

Abstract

Melanin has several physiological roles in maintaining health, but, notably, it affects the synthesis of vitamin D. Melanin is the primary determinant of the degree of skin pigmentation and protects the body from harmful ultraviolet radiation. Synthesis of 1,25-dihydroxyvitamin D(3) (1,25[OH](2)D(3)) in the skin, however, is dependent on ultraviolet B light. Highly pigmented skin, to the level found in people of African origin, abrogates almost all ultraviolet-induced 1,25(OH)(2)D(3) synthesis. Numerous animal models and clinical studies have underlined the essential role of vitamin D as a modulator of the different processes of the immune system. Evidence indicates that serum concentrations of 1,25(OH)(2)D(3) and the prevalence of autoimmune diseases in a certain population are associated with the latitude at which that population resides. This article explores the relationship between skin pigmentation, vitamin D and the prevalence of autoimmune disease.

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References

Petri M . Epidemiology of systemic lupus erythematosus. Best Pract Res Clin Rheumatol. 2002; 16(5):847-58. DOI: 10.1053/berh.2002.0259. View

Kamen D, Cooper G, Bouali H, Shaftman S, Hollis B, Gilkeson G . Vitamin D deficiency in systemic lupus erythematosus. Autoimmun Rev. 2006; 5(2):114-7. DOI: 10.1016/j.autrev.2005.05.009. View

van Etten E, Mathieu C . Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts. J Steroid Biochem Mol Biol. 2005; 97(1-2):93-101. DOI: 10.1016/j.jsbmb.2005.06.002. View

Shoenfeld Y, Zandman-Goddard G, Stojanovich L, Cutolo M, Amital H, Levy Y . The mosaic of autoimmunity: hormonal and environmental factors involved in autoimmune diseases--2008. Isr Med Assoc J. 2008; 10(1):8-12. View

Lalueza-Fox C, Rompler H, Caramelli D, Staubert C, Catalano G, Hughes D . A melanocortin 1 receptor allele suggests varying pigmentation among Neanderthals. Science. 2007; 318(5855):1453-5. DOI: 10.1126/science.1147417. View

Spach K, Nashold F, Dittel B, Hayes C . IL-10 signaling is essential for 1,25-dihydroxyvitamin D3-mediated inhibition of experimental autoimmune encephalomyelitis. J Immunol. 2006; 177(9):6030-7. DOI: 10.4049/jimmunol.177.9.6030. View

Lalueza-Fox C, Sampietro M, Caramelli D, Puder Y, Lari M, Calafell F . Neandertal evolutionary genetics: mitochondrial DNA data from the iberian peninsula. Mol Biol Evol. 2005; 22(4):1077-81. DOI: 10.1093/molbev/msi094. View

Schultz H . From infection to autoimmunity: a new model for induction of ANCA against the bactericidal/permeability increasing protein (BPI). Autoimmun Rev. 2007; 6(4):223-7. DOI: 10.1016/j.autrev.2006.08.005. View

Friedman A, Alarcon G, McGwin Jr G, Straaton K, Roseman J, Goel N . Systemic lupus erythematosus in three ethnic groups. IV. Factors associated with self-reported functional outcome in a large cohort study. LUMINA Study Group. Lupus in Minority Populations, Nature versus Nurture. Arthritis Care Res. 2000; 12(4):256-66. DOI: 10.1002/1529-0131(199908)12:4<256::aid-art4>3.0.co;2-g. View

10.

Ng K, Meyerhardt J, Wu K, Feskanich D, Hollis B, Giovannucci E . Circulating 25-hydroxyvitamin d levels and survival in patients with colorectal cancer. J Clin Oncol. 2008; 26(18):2984-91. DOI: 10.1200/JCO.2007.15.1027. View

11.

Kant A, Graubard B . Ethnicity is an independent correlate of biomarkers of micronutrient intake and status in American adults. J Nutr. 2007; 137(11):2456-63. DOI: 10.1093/jn/137.11.2456. View

12.

Cannell J, Hollis B . Use of vitamin D in clinical practice. Altern Med Rev. 2008; 13(1):6-20. View

13.

DeLuca H, Cantorna M . Vitamin D: its role and uses in immunology. FASEB J. 2001; 15(14):2579-85. DOI: 10.1096/fj.01-0433rev. View

14.

BLUM H . Does the melanin pigment of human skin have adaptive value? An essay in human skin have adaptive value? An essay in human ecology and the evolution of race. Q Rev Biol. 1961; 36:50-63. DOI: 10.1086/403275. View

15.

. Vitamin D supplement in early childhood and risk for Type I (insulin-dependent) diabetes mellitus. The EURODIAB Substudy 2 Study Group. Diabetologia. 1999; 42(1):51-4. DOI: 10.1007/s001250051112. View

16.

Griffin M, Lutz W, Phan V, Bachman L, McKean D, Kumar R . Potent inhibition of dendritic cell differentiation and maturation by vitamin D analogs. Biochem Biophys Res Commun. 2000; 270(3):701-8. DOI: 10.1006/bbrc.2000.2490. View

17.

Arnson Y, Amital H, Shoenfeld Y . Vitamin D and autoimmunity: new aetiological and therapeutic considerations. Ann Rheum Dis. 2007; 66(9):1137-42. PMC: 1955167. DOI: 10.1136/ard.2007.069831. View

18.

Borgogni E, Sarchielli E, Sottili M, Santarlasci V, Cosmi L, Gelmini S . Elocalcitol inhibits inflammatory responses in human thyroid cells and T cells. Endocrinology. 2008; 149(7):3626-34. DOI: 10.1210/en.2008-0078. View

19.

Lamb E, Wong T, Smith D, Simpson D, Coakley A, Moniz C . Metabolic bone disease is present at diagnosis in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2002; 16(11):1895-902. DOI: 10.1046/j.1365-2036.2002.01363.x. View

20.

Branda R, Eaton J . Skin color and nutrient photolysis: an evolutionary hypothesis. Science. 1978; 201(4356):625-6. DOI: 10.1126/science.675247. View