Periodontitis Relates to Benign Prostatic Hyperplasia Via the Gut Microbiota and Fecal Metabolome

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2024 Jan 1

PMID 38163068

Authors

Xing-Pei Guo

Jun Yang

Lan Wu

Cheng Fang

Jia-Min Gu

Fei Li

Han-Song Liu

Lu-Yao Li

Shuang-Ying Wang

Affiliations

Soon will be listed here.

Abstract

Objectives: Periodontitis is associated with benign prostatic hyperplasia (BPH), whether it related to gut floramicrobiota and metabonomics is unclear.

Methods: We established ligature-induced periodontitis (EP), testosterone-induced BPH, and composite rat models. Fecal samples were collected to detect gut microbiota by 16S rDNA sequencing and metabonomics were detected by liquid chromatography tandem mass spectrometry (LC-MS/MS).

Results: Sequencing results revealed differential gut floramicrobiota composition between EP+BPH group and other three groups. The abundances of were significantly increased in EP+BPH group compared with other groups. , and were significantly decreased in EP+BPH group compared with BPH group, while and Escherichia were significantly decreased compared with EP group. For gut metabonomics, LC-MS/MS showed that fecal metabolites and seven metabolic pathways were changed in EP+BPH group, such as biosynthesis of unsaturated fatty acids, steroid hormone biosynthesis. Correlation analysis showed that the alterations of gut metabolism were significantly correlated with differential gut floramicrobiota, such as and .

Conclusion: Our study highlights the relationship of periodontitis and BPH, the alterations of gut floramicrobiota and metabolites may be involved in two diseases, which provides new idea for prevention and treatment of patients with periodontitis concurrent BPH.

Citing Articles

Chronic Periodontitis as a Risk Factor for Benign Prostatic Hyperplasia: A Cohort Study.

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Wei H, Tian G, Xu S, Du Y, Li M, Wang Y Front Genet. 2024; 15:1326434.

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