High Fat Diet, Gut Microbiome and Gastrointestinal Cancer

Overview

Journal Theranostics

Date 2021 Apr 26

PMID 33897888

Citations 72

Authors

Yao Tong

Huiru Gao

Qiuchen Qi

Xiaoyan Liu

Juan Li

Jie Gao

Peilong Li

Yunshan Wang

Lutao Du

Chuanxin Wang

Affiliations

Soon will be listed here.

Abstract

Gastrointestinal cancer is currently one of the main causes of cancer death, with a large number of cases and a wide range of lesioned sites. A high fat diet, as a public health problem, has been shown to be correlated with various digestive system diseases and tumors, and can accelerate the occurrence of cancer due to inflammation and altered metabolism. The gut microbiome has been the focus of research in recent years, and associated with cell damage or tumor immune microenvironment changes via direct or extra-intestinal effects; this may facilitate the occurrence and development of gastrointestinal tumors. Based on research showing that both a high fat diet and gut microbes can promote the occurrence of gastrointestinal tumors, and that a high fat diet imbalances intestinal microbes, we propose that a high fat diet drives gastrointestinal tumors by changing the composition of intestinal microbes.

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