Sex Differences in the Relationship Between Post-vaccination Adverse Reactions, Decision Regret, and WTP for the Booster Dose of COVID-19 Vaccine in Taizhou, China

Overview

Journal Prev Med Rep

Date 2024 Jan 1

PMID 38162118

Authors

Chengwen Luo

Hai-Xiao Chen

Tao-Hsin Tung

Affiliations

Soon will be listed here.

Abstract

This study investigated sex differences in the relationship between post-vaccination adverse reactions, decision regret, and willingness to pay (WTP) for the booster dose of COVID-19 vaccines. This research carried out an online cross-sectional investigation among healthcare workers (HCWs) in Taizhou, China. In total, 1,054 respondents (165 males and 889 females) have received two-dose COVID-19 vaccination. We performed descriptive analysis, chi-square test, and mediation analysis on the exported data. In this study, 67 (40.6%) males and 429 (48.3%) females had WTP for the booster dose. Our study presented that decision regret mediated the effect of adverse reactions after vaccination on WTP for the booster dose in both male and female groups. In males, decision regret played a completely mediating role, while in females, it acted as a partial mediator. Sex differences in the relationship between post-vaccination side effects, decision regret, and WTP for the third dose were demonstrated in a sample of healthcare workers.

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References

Rozenberg S, Vandromme J, Martin C . Are we equal in adversity? Does Covid-19 affect women and men differently?. Maturitas. 2020; 138:62-68. PMC: 7227588. DOI: 10.1016/j.maturitas.2020.05.009. View

Wiersinga W, Rhodes A, Cheng A, Peacock S, Prescott H . Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review. JAMA. 2020; 324(8):782-793. DOI: 10.1001/jama.2020.12839. View

Harapan H, Sallam M, Fathima R, Kusuma H, Anwar S, Nalapraya W . Willingness to Pay (WTP) for COVID-19 Vaccine Booster Dose and Its Determinants in Indonesia. Infect Dis Rep. 2022; 14(6):1017-1032. PMC: 9778827. DOI: 10.3390/idr14060101. View

Palacios R, Patino E, Piorelli R, Conde M, Batista A, Zeng G . Double-Blind, Randomized, Placebo-Controlled Phase III Clinical Trial to Evaluate the Efficacy and Safety of treating Healthcare Professionals with the Adsorbed COVID-19 (Inactivated) Vaccine Manufactured by Sinovac - PROFISCOV: A structured summary.... Trials. 2020; 21(1):853. PMC: 7558252. DOI: 10.1186/s13063-020-04775-4. View

Harapan H, Itoh N, Yufika A, Winardi W, Keam S, Te H . Coronavirus disease 2019 (COVID-19): A literature review. J Infect Public Health. 2020; 13(5):667-673. PMC: 7142680. DOI: 10.1016/j.jiph.2020.03.019. View

Majumder J, Minko T . Recent Developments on Therapeutic and Diagnostic Approaches for COVID-19. AAPS J. 2021; 23(1):14. PMC: 7784226. DOI: 10.1208/s12248-020-00532-2. View

Salman M, Mallhi T, Tanveer N, Shehzadi N, Majeed Khan H, Ul Mustafa Z . Evaluation of Conspiracy Beliefs, Vaccine Hesitancy, and Willingness to Pay towards COVID-19 Vaccines in Six Countries from Asian and African Regions: A Large Multinational Analysis. Vaccines (Basel). 2022; 10(11). PMC: 9694922. DOI: 10.3390/vaccines10111866. View

Mengistu D, Demmu Y, Asefa Y . Global COVID-19 vaccine acceptance rate: Systematic review and meta-analysis. Front Public Health. 2022; 10:1044193. PMC: 9773145. DOI: 10.3389/fpubh.2022.1044193. View

Ripabelli G, Tamburro M, Buccieri N, Adesso C, Caggiano V, Cannizzaro F . Active Surveillance of Adverse Events in Healthcare Workers Recipients After Vaccination with COVID-19 BNT162b2 Vaccine (Pfizer-BioNTech, Comirnaty): A Cross-Sectional Study. J Community Health. 2021; 47(2):211-225. PMC: 8501918. DOI: 10.1007/s10900-021-01039-3. View

10.

Tamburro M, Ripabelli G, DAmico A, DE Dona R, Iafigliola M, Parente A . A Cross-Sectional Study of Untoward Reactions Following Homologous and Heterologous COVID-19 Booster Immunizations in Recipients Seventeen Years of Age and Older. J Community Health. 2022; 47(5):814-821. PMC: 9244372. DOI: 10.1007/s10900-022-01112-5. View

11.

Zhu J, Zhang M, Chien C, Yang W, Shi G, Qiu S . Sex Differences in Adverse Reactions to an Inactivated SARS-CoV-2 Vaccine Among Medical Staff in China. Front Med (Lausanne). 2021; 8:731593. PMC: 8455952. DOI: 10.3389/fmed.2021.731593. View

12.

Kalucka S, Kusidel E, Glowacka A, Oczos P, Grzegorczyk-Karolak I . Pre-Vaccination Stress, Post-Vaccination Adverse Reactions, and Attitudes towards Vaccination after Receiving the COVID-19 Vaccine among Health Care Workers. Vaccines (Basel). 2022; 10(3). PMC: 8952304. DOI: 10.3390/vaccines10030401. View

13.

Sabetian G, Moghadami M, Hashemizadeh Fard Haghighi L, Shahriarirad R, Fallahi M, Asmarian N . COVID-19 infection among healthcare workers: a cross-sectional study in southwest Iran. Virol J. 2021; 18(1):58. PMC: 7968574. DOI: 10.1186/s12985-021-01532-0. View

14.

Merga B, Ayana G, Negash B, Alemu A, Abdurke M, Abdu A . Health-care Workers' Willingness to Pay for COVID-19 Vaccines in Eastern Ethiopia: Using Contingent Valuation Method. Clinicoecon Outcomes Res. 2022; 14:395-404. PMC: 9126155. DOI: 10.2147/CEOR.S361199. View

15.

Lazarus J, Ratzan S, Palayew A, Gostin L, Larson H, Rabin K . A global survey of potential acceptance of a COVID-19 vaccine. Nat Med. 2020; 27(2):225-228. PMC: 7573523. DOI: 10.1038/s41591-020-1124-9. View

16.

Cheng Y, Li T, Zheng Y, Xu B, Bi Y, Hu Y . Self-Reported adverse events among Chinese healthcare workers immunized with COVID-19 vaccines composed of inactivated SARS-CoV-2. Hum Vaccin Immunother. 2022; 18(5):2064134. PMC: 9897645. DOI: 10.1080/21645515.2022.2064134. View

17.

Shitu K, Wolde M, Handebo S, Kassie A . Acceptance and willingness to pay for COVID-19 vaccine among school teachers in Gondar City, Northwest Ethiopia. Trop Med Health. 2021; 49(1):63. PMC: 8352142. DOI: 10.1186/s41182-021-00337-9. View

18.

Zhang M, Zhang T, Shi G, Cheng F, Zheng Y, Tung T . Safety of an inactivated SARS-CoV-2 vaccine among healthcare workers in China. Expert Rev Vaccines. 2021; 20(7):891-898. PMC: 8127168. DOI: 10.1080/14760584.2021.1925112. View

19.

Noushad M, Rastam S, Nassani M, Al-Saqqaf I, Hussain M, Yaroko A . A Global Survey of COVID-19 Vaccine Acceptance Among Healthcare Workers. Front Public Health. 2022; 9:794673. PMC: 8860987. DOI: 10.3389/fpubh.2021.794673. View

20.

Haun M, Schakowski A, Preibsch A, Friederich H, Hartmann M . Assessing decision regret in caregivers of deceased German people with cancer-A psychometric validation of the Decision Regret Scale for Caregivers. Health Expect. 2019; 22(5):1089-1099. PMC: 6803409. DOI: 10.1111/hex.12941. View