Characteristics and Incidence of Cardiac Events Across Spectrum of Age in Cardiac Sarcoidosis

Overview

Journal Int J Cardiol Heart Vasc

Date 2024 Jan 1

PMID 38161782

Authors

Takeru Nabeta

Shingo Matsumoto

Shunsuke Ishii

Yuko Eda

Mayu Yazaki

Teppei Fujita

Yuichiro Iida

Yuki Ikeda

Takeshi Kitai

Yoshihisa Naruse

Tatsunori Taniguchi

Kenji Yoshioka

Hidekazu Tanaka

Takahiro Okumura

Yuichi Baba

Yuya Matsue

Junya Ako

Affiliations

Soon will be listed here.

Abstract

Background: Clinical characteristics and the risk of cardiovascular events in patients with cardiac sarcoidosis (CS) according to the age of initial diagnosis are unclear.

Methods: This study is a sub-analysis of the ILLUMINATE-CS registry, which is a retrospective, multicenter registry that enrolled patients with CS between 2001 and 2017. Patients were divided into three groups according to the tertile of age at the time of initial diagnosis of CS. The study compared the clinical background at the time of CS diagnosis and the incidence rate of cardiac events across age categories.

Results: A total of 511 patients were analyzed in this study. In baseline, older patients were more likely to be female. History of hypertension, heart failure admission, and atrioventricular block were more common in patients with older age. There was no significant difference in the history of ventricular arrhythmias and left ventricular ejection fraction among all age groups. During a median follow-up period of 3.2 [IQR: 1.7-4.2] years, 35 deaths, 56 heart failure hospitalization, and 98 fatal ventricular arrhythmias was observed. The incidence rate of all-cause death and heart failure hospitalization was significantly higher in patients with older age (p < 0.001), while there was no significant difference in the incidence rate of ventricular arrhythmia among age groups (p = 0.74).

Conclusions: In patients with CS, the risk of all-cause death and heart failure hospitalization was higher in older patients compared with other age groups; however, the risk of ventricular arrhythmia was comparable across all age groups.

Citing Articles

Arrhythmias in Cardiac Sarcoidosis: Management and Prognostic Implications.

Arunachalam Karikalan S, Yusuf A, El Masry H J Clin Med. 2024; 13(11).

PMID: 38892878 PMC: 11172558. DOI: 10.3390/jcm13113165.

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