Functional Features of a Novel Interferon-stimulated Gene SHFL: a Comprehensive Review

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2023 Dec 27

PMID 38149274

Authors

Xingzheng Wang

A-Mei Zhang

Affiliations

Soon will be listed here.

Abstract

Various interferon (IFN)-stimulated genes (ISGs), expressed via Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway-stimulated IFNs to increase antiviral effects or regulate immune response, perform different roles in virus-infected cells. In recent years, a novel ISG, , which is located in the genomic region 19p13.2 and comprises two isoforms, has been studied as a virus-inhibiting agent. Studies have shown that SHFL suppressive effects on human immunodeficiency virus-1 (HIV), Zika virus (ZIKV), dengue virus (DENV), hepatitis C virus (HCV), Japanese encephalitis virus (JEV), porcine epidemic diarrhea virus (PEDV), Human enterovirus A71 (EV-A71) and Kaposi's sarcoma-associated herpes virus (KSHV). SHFL interacts with various viral and host molecules to inhibit viral life circle and activities, such as replication, translation, and ribosomal frameshifting, or regulates host pathways to degrade viral proteins. In this review, we summarized the functional features of SHFL to provide insights to underlying mechanisms of the antiviral effects of SHFL and explored its potential function.

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References

Schoggins J, Wilson S, Panis M, Murphy M, Jones C, Bieniasz P . A diverse range of gene products are effectors of the type I interferon antiviral response. Nature. 2011; 472(7344):481-5. PMC: 3409588. DOI: 10.1038/nature09907. View

Woodson C, Kehn-Hall K . Examining the role of EGR1 during viral infections. Front Microbiol. 2022; 13:1020220. PMC: 9634628. DOI: 10.3389/fmicb.2022.1020220. View

Liu N, Liu M, Yang J, Dong S, Yue M, Huang P . Association of genetic polymorphisms in the gene and biochemical indices of HBV infected individuals in Yunnan. Front Cell Infect Microbiol. 2023; 13:1180366. PMC: 10245551. DOI: 10.3389/fcimb.2023.1180366. View

Li Q, Sun B, Zhuo Y, Jiang Z, Li R, Lin C . Interferon and interferon-stimulated genes in HBV treatment. Front Immunol. 2022; 13:1034968. PMC: 9751411. DOI: 10.3389/fimmu.2022.1034968. View

Zhang A, Ma K, Song Y, Wang B, Feng Y, Liu L . Genetic polymorphisms of the IFNλ genes are associated with biochemical features in Han Chinese with HCV infection from Yunnan Province, China. Infect Genet Evol. 2013; 21:161-5. DOI: 10.1016/j.meegid.2013.11.013. View

White M, Wollebo H, Beckham J, Tyler K, Khalili K . Zika virus: An emergent neuropathological agent. Ann Neurol. 2016; 80(4):479-89. PMC: 5086418. DOI: 10.1002/ana.24748. View

Yuan J, Shen L, Wu J, Zou X, Gu J, Chen J . Enterovirus A71 Proteins: Structure and Function. Front Microbiol. 2018; 9:286. PMC: 5826392. DOI: 10.3389/fmicb.2018.00286. View

Wang H, Kong N, Jiao Y, Dong S, Sun D, Chen X . EGR1 Suppresses Porcine Epidemic Diarrhea Virus Replication by Regulating IRAV To Degrade Viral Nucleocapsid Protein. J Virol. 2021; 95(19):e0064521. PMC: 8428380. DOI: 10.1128/JVI.00645-21. View

Rodriguez W, Mehrmann T, Hatfield D, Muller M . Shiftless Restricts Viral Gene Expression and Influences RNA Granule Formation during Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication. J Virol. 2022; 96(22):e0146922. PMC: 9682979. DOI: 10.1128/jvi.01469-22. View

10.

Boulikas T . Putative nuclear localization signals (NLS) in protein transcription factors. J Cell Biochem. 1994; 55(1):32-58. DOI: 10.1002/jcb.240550106. View

11.

Kinast V, Plociennikowska A, Anggakusuma , Bracht T, Todt D, Brown R . C19orf66 is an interferon-induced inhibitor of HCV replication that restricts formation of the viral replication organelle. J Hepatol. 2020; 73(3):549-558. DOI: 10.1016/j.jhep.2020.03.047. View

12.

Sharma K, Vrati S, Kalia M . Pathobiology of Japanese encephalitis virus infection. Mol Aspects Med. 2021; 81:100994. DOI: 10.1016/j.mam.2021.100994. View

13.

Napthine S, Hill C, Nugent H, Brierley I . Modulation of Viral Programmed Ribosomal Frameshifting and Stop Codon Readthrough by the Host Restriction Factor Shiftless. Viruses. 2021; 13(7). PMC: 8310280. DOI: 10.3390/v13071230. View

14.

Yun S, Lee Y . Japanese encephalitis: the virus and vaccines. Hum Vaccin Immunother. 2013; 10(2):263-79. PMC: 4185882. DOI: 10.4161/hv.26902. View

15.

Sun R, Cai R, Chen Y, Liang P, Chen D, Song C . Outbreak of porcine epidemic diarrhea in suckling piglets, China. Emerg Infect Dis. 2012; 18(1):161-3. PMC: 3381683. DOI: 10.3201/eid1801.111259. View

16.

Chen K, Liu J, Cao X . Regulation of type I interferon signaling in immunity and inflammation: A comprehensive review. J Autoimmun. 2017; 83:1-11. DOI: 10.1016/j.jaut.2017.03.008. View

17.

Hanners N, Mar K, Boys I, Eitson J, Cruz-Rivera P, Richardson R . Shiftless inhibits flavivirus replication in vitro and is neuroprotective in a mouse model of Zika virus pathogenesis. Proc Natl Acad Sci U S A. 2021; 118(49). PMC: 8670505. DOI: 10.1073/pnas.2111266118. View

18.

Kok B, Lim H, Lim C, Lai N, Leow C, Leow C . Dengue virus infection - a review of pathogenesis, vaccines, diagnosis and therapy. Virus Res. 2022; 324:199018. PMC: 10194131. DOI: 10.1016/j.virusres.2022.199018. View

19.

Tan C, Qin X, Tan Y, Dong X, Chen D, Liang L . SHFL inhibits enterovirus A71 infection by triggering degradation of viral 3D protein via the ubiquitin-proteasome pathway. J Med Virol. 2023; 95(8):e29030. DOI: 10.1002/jmv.29030. View

20.

Zhang Y, Kinast V, Sheldon J, Frericks N, Todt D, Zimmer M . Mouse Liver-Expressed Shiftless Is an Evolutionarily Conserved Antiviral Effector Restricting Human and Murine Hepaciviruses. Microbiol Spectr. 2023; 11(4):e0128423. PMC: 10433982. DOI: 10.1128/spectrum.01284-23. View