Specifics of Pharmacokinetics and Biodistribution of 5-Fluorouracil Polymeric Complex

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2023 Dec 23

PMID 38138585

Authors

Olga V Zhukova

Natalya A Dubovskaya

Daria A Zykova

Evgenia V Arkhipova

Olga A Vorobeva

Olga G Zaborskaya

Sergey D Zaitsev

Alexandra O Grigoreva

Aleksandr A Chicharov

Sergey A Ryabov

Affiliations

Soon will be listed here.

Abstract

Materials And Methods: Monomeric methacrylic acid was used to synthesize polymers; 2-phenylpropane-2-ilbenzodithioate was used for the synthesis of poly(methacrylic acid). To study the molecular-weight characteristics of poly(methacrylic acid) by gel permeation chromatography, an experimental neoplasm model was obtained by grafting PC-1 cancer cells. Blood samples were drawn from the tail vein at different points in time. The rats were sacrificed via decapitation after drawing the last pharmacokinetic blood sample. To study the biodistribution, internal organs were isolated and analyzed. The measurements were carried out by high-performance liquid chromatography.

Results: Our results demonstrate that incorporation in a polymeric complex changes the pharmacokinetics and biodistribution profile of 5-FU. The polymeric complex was shown to accumulate to a higher level in the lung and spleen.

Conclusion: The results obtained are the basis for further studies to verify the efficacy of the 5-Fluorouracil polymeric complex.

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