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The Role of Irisin Throughout Women's Life Span

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Journal Biomedicines
Date 2023 Dec 23
PMID 38137481
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Abstract

Since its discovery, much attention has been drawn to irisin's potential role in metabolic and reproductive diseases. This narrative review summarizes and updates the possible role played by this fascinating molecule in different physiological (puberty and menopause) and pathological (polycystic ovary syndrome (PCOS), functional hypothalamic amenorrhea (FHA), endometriosis, and gestational diabetes) conditions that can affect women throughout their entire lives. Irisin appears to be an important factor for the hypothalamic-pituitary-gonadal axis activation, and appears to play a role in the timing of puberty onset. Serum irisin levels have been proposed as a biomarker for predicting the future development of gestational diabetes (GDM). Its role in PCOS is still controversial, although an "irisin resistance" mechanism has been hypothesized. In addition to its impact on metabolism, irisin also appears to influence bone health. Irisin levels are inversely correlated with the prevalence of fractures in postmenopausal women. Similar mechanisms have also been postulated in young women with FHA. In clinical settings, further controlled, prospective and randomized clinical trials are needed to investigate the casual relationship between irisin levels and the conditions described and, in turn, to establish the role of irisin as a prognostic/diagnostic biomarker or a therapeutic target.

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References
1.
Chen X, Sun K, Zhao S, Geng T, Fan X, Sun S . Irisin promotes osteogenic differentiation of bone marrow mesenchymal stem cells by activating autophagy via the Wnt//β-catenin signal pathway. Cytokine. 2020; 136:155292. DOI: 10.1016/j.cyto.2020.155292. View

2.
Sanchez-Garrido M, Tena-Sempere M . Metabolic control of puberty: roles of leptin and kisspeptins. Horm Behav. 2013; 64(2):187-94. DOI: 10.1016/j.yhbeh.2013.01.014. View

3.
Silva B, Costa A, Cusano N, Kousteni S, Bilezikian J . Catabolic and anabolic actions of parathyroid hormone on the skeleton. J Endocrinol Invest. 2011; 34(10):801-10. PMC: 4315330. DOI: 10.3275/7925. View

4.
Moon H, Dincer F, Mantzoros C . Pharmacological concentrations of irisin increase cell proliferation without influencing markers of neurite outgrowth and synaptogenesis in mouse H19-7 hippocampal cell lines. Metabolism. 2013; 62(8):1131-6. PMC: 4370428. DOI: 10.1016/j.metabol.2013.04.007. View

5.
Abali R, Yuksel I, Yuksel M, Bulut B, Imamoglu M, Emirdar V . Implications of circulating irisin and Fabp4 levels in patients with polycystic ovary syndrome. J Obstet Gynaecol. 2016; 36(7):897-901. DOI: 10.3109/01443615.2016.1174200. View