The Roles of WNT Signaling Pathways in Skin Development and Mechanical-Stretch-Induced Skin Regeneration

Overview

Journal Biomolecules

Publisher MDPI

Specialties Biochemistry
Molecular Biology

Date 2023 Dec 23

PMID 38136575

Authors

Ruoxue Bai

Yaotao Guo

Wei Liu

Yajuan Song

Zhou Yu

Xianjie Ma

Affiliations

Soon will be listed here.

Abstract

The WNT signaling pathway plays a critical role in a variety of biological processes, including development, adult tissue homeostasis maintenance, and stem cell regulation. Variations in skin conditions can influence the expression of the WNT signaling pathway. In light of the above, a deeper understanding of the specific mechanisms of the WNT signaling pathway in different physiological and pathological states of the skin holds the potential to significantly advance clinical treatments of skin-related diseases. In this review, we present a comprehensive analysis of the molecular and cellular mechanisms of the WNT signaling pathway in skin development, wound healing, and mechanical stretching. Our review sheds new light on the crucial role of the WNT signaling pathway in the regulation of skin physiology and pathology.

Citing Articles

Rifampicin Repurposing Reveals Anti-Melanogenic Activity in B16F10 Melanoma Cells.

Lee Y, Hyun C Molecules. 2025; 30(4).

PMID: 40005210 PMC: 11858211. DOI: 10.3390/molecules30040900.

Recombinant human collagen XVII protects skin basement membrane integrity by inhibiting the MAPK and Wnt signaling pathways.

Wang J, Lin S, Wei Y, Ye Z Mol Med Rep. 2025; 31(4).

PMID: 39981899 PMC: 11868773. DOI: 10.3892/mmr.2025.13465.

The Role of Bovine Milk-Derived Exosomes in Human Health and Disease.

Jablonska M, Sawicki T, Zulewska J, Staniewska K, Lobacz A, Przybylowicz K Molecules. 2025; 29(24.

PMID: 39769923 PMC: 11728725. DOI: 10.3390/molecules29245835.

Integration Analysis of Transcriptome Sequencing and Whole-Genome Resequencing Reveal Wool Quality-Associated Key Genes in Zhexi Angora Rabbits.

Zhao B, Yu Y, Sun S, Cai J, Bao Z, Chen Y Vet Sci. 2024; 11(12).

PMID: 39728991 PMC: 11680169. DOI: 10.3390/vetsci11120651.

YAP/TAZ Signalling Controls Epidermal Keratinocyte Fate.

Pankratova M, Riabinin A, Butova E, Selivanovskiy A, Morgun E, Ulianov S Int J Mol Sci. 2024; 25(23).

PMID: 39684613 PMC: 11641583. DOI: 10.3390/ijms252312903.

References

Caraci F, Gili E, Calafiore M, Failla M, La Rosa C, Crimi N . TGF-beta1 targets the GSK-3beta/beta-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts. Pharmacol Res. 2008; 57(4):274-82. DOI: 10.1016/j.phrs.2008.02.001. View

Lin H, Angeli M, Chung K, Ejimadu C, Rosa A, Lee T . sFRP2 activates Wnt/β-catenin signaling in cardiac fibroblasts: differential roles in cell growth, energy metabolism, and extracellular matrix remodeling. Am J Physiol Cell Physiol. 2016; 311(5):C710-C719. PMC: 5130588. DOI: 10.1152/ajpcell.00137.2016. View

Huang X, Liang X, Zhou Y, Du H, Suo Y, Liu W . CDH1 is Identified as A Therapeutic Target for Skin Regeneration after Mechanical Loading. Int J Biol Sci. 2021; 17(1):353-367. PMC: 7757047. DOI: 10.7150/ijbs.51309. View

Li Y, Bu G . LRP5/6 in Wnt signaling and tumorigenesis. Future Oncol. 2006; 1(5):673-81. DOI: 10.2217/14796694.1.5.673. View

Nusse R . Developmental biology. Making head or tail of Dickkopf. Nature. 2001; 411(6835):255-6. DOI: 10.1038/35077199. View

Shi Y, Shu B, Yang R, Xu Y, Xing B, Liu J . Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately. Stem Cell Res Ther. 2015; 6:120. PMC: 4501079. DOI: 10.1186/s13287-015-0103-4. View

Liang X, Huang X, Zhou Y, Jin R, Li Q . Mechanical Stretching Promotes Skin Tissue Regeneration via Enhancing Mesenchymal Stem Cell Homing and Transdifferentiation. Stem Cells Transl Med. 2016; 5(7):960-9. PMC: 4922851. DOI: 10.5966/sctm.2015-0274. View

Deckers J, Hammad H, Hoste E . Langerhans Cells: Sensing the Environment in Health and Disease. Front Immunol. 2018; 9:93. PMC: 5799717. DOI: 10.3389/fimmu.2018.00093. View

Le S, Yu M, Yan J . Phosphorylation Reduces the Mechanical Stability of the α-Catenin/ β-Catenin Complex. Angew Chem Int Ed Engl. 2019; 58(51):18663-18669. PMC: 6916283. DOI: 10.1002/anie.201911383. View

10.

Chen H, Wang X, Han J, Fan Z, Sadia S, Zhang R . AKT and its related molecular feature in aged mice skin. PLoS One. 2017; 12(6):e0178969. PMC: 5462418. DOI: 10.1371/journal.pone.0178969. View

11.

Liu S, Ding J, Zhang Y, Cheng X, Dong C, Song Y . Establishment of a Novel Mouse Model for Soft Tissue Expansion. J Surg Res. 2020; 253:238-244. DOI: 10.1016/j.jss.2020.03.005. View

12.

Ponnusamy Y, Chear N, Ramanathan S, Lai C . Polyphenols rich fraction of Dicranopteris linearis promotes fibroblast cell migration and proliferation in vitro. J Ethnopharmacol. 2015; 168:305-14. DOI: 10.1016/j.jep.2015.03.062. View

13.

Cui C, Yin M, Sima J, Childress V, Michel M, Piao Y . Involvement of Wnt, Eda and Shh at defined stages of sweat gland development. Development. 2014; 141(19):3752-60. PMC: 4197578. DOI: 10.1242/dev.109231. View

14.

MBoneko V, Merker H . Development and morphology of the periderm of mouse embryos (days 9-12 of gestation). Acta Anat (Basel). 1988; 133(4):325-36. DOI: 10.1159/000146662. View

15.

Kemler R . From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion. Trends Genet. 1993; 9(9):317-21. DOI: 10.1016/0168-9525(93)90250-l. View

16.

Ledwon J, Kelsey L, Vaca E, Gosain A . Transcriptomic analysis reveals dynamic molecular changes in skin induced by mechanical forces secondary to tissue expansion. Sci Rep. 2020; 10(1):15991. PMC: 7524724. DOI: 10.1038/s41598-020-71823-z. View

17.

Witte F, Bernatik O, Kirchner K, Masek J, Mahl A, Krejci P . Negative regulation of Wnt signaling mediated by CK1-phosphorylated Dishevelled via Ror2. FASEB J. 2010; 24(7):2417-26. DOI: 10.1096/fj.09-150615. View

18.

Hsu Y, Li L, Fuchs E . Emerging interactions between skin stem cells and their niches. Nat Med. 2014; 20(8):847-56. PMC: 4358898. DOI: 10.1038/nm.3643. View

19.

Koh T, DiPietro L . Inflammation and wound healing: the role of the macrophage. Expert Rev Mol Med. 2011; 13:e23. PMC: 3596046. DOI: 10.1017/S1462399411001943. View

20.

Plikus M, Mayer J, de la Cruz D, Baker R, Maini P, Maxson R . Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration. Nature. 2008; 451(7176):340-4. PMC: 2696201. DOI: 10.1038/nature06457. View