AKT and Its Related Molecular Feature in Aged Mice Skin

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2017 Jun 8

PMID 28591208

Citations 22

Authors

Haiyan Chen

Xusheng Wang

Jimin Han

Zhimeng Fan

Sobia Sadia

Rongrong Zhang

Yingsheng Guo

Yuyang Jiang

Yaojiong Wu

Affiliations

Soon will be listed here.

Abstract

Previous studies suggest that Akt signaling promotes tissue regeneration and decreased Akt activities are found in aged tissues. However, this study finds that the expression and activation levels of Akt in the mice skin increased with age. Additionally, the expression levels of Pten, p16, p21 and p53 also elevated with increased age. Immuno-fluorescence analysis showed that Akt phosphorylation found in the epidermal cells (with increased levels of NF-κB activation) were also found. In vivo inhibition of AKT activity result in reduced NF-κB activation. Our results suggest that increasing Akt/ NF-κB is a crucial mediator of skin aging, which can increase the susceptibility of cell transformation.

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