Mechanisms and Therapeutic Strategies of Extracellular Vesicles in Cardiovascular Diseases

Overview

Journal MedComm (2020)

Specialty Health Services

Date 2023 Dec 21

PMID 38124785

Authors

Qirong Li

Qiang Feng

Hengzong Zhou

Chao Lin

Xiaoming Sun

Chaoyang Ma

Liqun Sun

Gongliang Guo

Dongxu Wang

Affiliations

Soon will be listed here.

Abstract

Cardiovascular disease (CVD) significantly impacts global society since it is the leading cause of death and disability worldwide, and extracellular vesicle (EV)-based therapies have been extensively investigated. EV delivery is involved in mediating the progression of CVDs and has great potential to be biomarker and therapeutic molecular carrier. Besides, EVs from stem cells and cardiac cells can effectively protect the heart from various pathologic conditions, and then serve as an alternative treatment for CVDs. Moreover, the research of using EVs as delivery carriers of therapeutic molecules, membrane engineering modification of EVs, or combining EVs with biomaterials further improves the application potential of EVs in clinical treatment. However, currently there are only a few articles summarizing the application of EVs in CVDs. This review provides an overview of the role of EVs in the pathogenesis and diagnosis of CVDs. It also focuses on how EVs promote the repair of myocardial injury and therapeutic methods of CVDs. In conclusion, it is of great significance to review the research on the application of EVs in the treatment of CVDs, which lays a foundation for further exploration of the role of EVs, and clarifies the prospect of EVs in the treatment of myocardial injury.

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References

Xiao J, Pan Y, Li X, Yang X, Feng Y, Tan H . Cardiac progenitor cell-derived exosomes prevent cardiomyocytes apoptosis through exosomal miR-21 by targeting PDCD4. Cell Death Dis. 2016; 7(6):e2277. PMC: 5143405. DOI: 10.1038/cddis.2016.181. View

Xiao C, Wang K, Xu Y, Hu H, Zhang N, Wang Y . Transplanted Mesenchymal Stem Cells Reduce Autophagic Flux in Infarcted Hearts via the Exosomal Transfer of miR-125b. Circ Res. 2018; 123(5):564-578. DOI: 10.1161/CIRCRESAHA.118.312758. View

Crewe C, Funcke J, Li S, Joffin N, Gliniak C, Ghaben A . Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes. Cell Metab. 2021; 33(9):1853-1868.e11. PMC: 8429176. DOI: 10.1016/j.cmet.2021.08.002. View

Lai T, Lee T, Chang Y, Chen Y, Lin S, Lin S . MicroRNA-221/222 Mediates ADSC-Exosome-Induced Cardioprotection Against Ischemia/Reperfusion by Targeting PUMA and ETS-1. Front Cell Dev Biol. 2020; 8:569150. PMC: 7744807. DOI: 10.3389/fcell.2020.569150. View

Hegyesi H, Pallinger E, Mecsei S, Hornyak B, Kovacshazi C, Brenner G . Circulating cardiomyocyte-derived extracellular vesicles reflect cardiac injury during systemic inflammatory response syndrome in mice. Cell Mol Life Sci. 2022; 79(2):84. PMC: 8776681. DOI: 10.1007/s00018-021-04125-w. View

Cheng P, Cheng L, Han H, Li J, Ma C, Huang H . A pH/H O /MMP9 Time-Response Gel System with Sparc Tregs Derived Extracellular Vesicles Promote Recovery After Acute Myocardial Infarction. Adv Healthc Mater. 2022; 11(22):e2200971. DOI: 10.1002/adhm.202200971. View

Oggero S, de Gaetano M, Marcone S, Fitzsimons S, Pinto A, Ikramova D . Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque reactivity. J Extracell Vesicles. 2021; 10(6):12084. PMC: 8077084. DOI: 10.1002/jev2.12084. View

Sun P, Wang C, Mang G, Xu X, Fu S, Chen J . Extracellular vesicle-packaged mitochondrial disturbing miRNA exacerbates cardiac injury during acute myocardial infarction. Clin Transl Med. 2022; 12(4):e779. PMC: 9028097. DOI: 10.1002/ctm2.779. View

Jung J, Ikeda G, Tada Y, von Bornstadt D, Santoso M, Wahlquist C . miR-106a-363 cluster in extracellular vesicles promotes endogenous myocardial repair via Notch3 pathway in ischemic heart injury. Basic Res Cardiol. 2021; 116(1):19. PMC: 8601755. DOI: 10.1007/s00395-021-00858-8. View

10.

Roth G, Johnson C, Abajobir A, Abd-Allah F, Abera S, Abyu G . Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015. J Am Coll Cardiol. 2017; 70(1):1-25. PMC: 5491406. DOI: 10.1016/j.jacc.2017.04.052. View

11.

Wang J, Lee C, Deci M, Jasiewicz N, Verma A, Canty J . MiR-101a loaded extracellular nanovesicles as bioactive carriers for cardiac repair. Nanomedicine. 2020; 27:102201. PMC: 7647388. DOI: 10.1016/j.nano.2020.102201. View

12.

Mayhall E, Paffett-Lugassy N, Zon L . The clinical potential of stem cells. Curr Opin Cell Biol. 2004; 16(6):713-20. DOI: 10.1016/j.ceb.2004.09.007. View

13.

Pecan P, Hambalko S, Ha V, Nagy C, Pelyhe C, Lainscek D . Calcium Ionophore-Induced Extracellular Vesicles Mediate Cytoprotection against Simulated Ischemia/Reperfusion Injury in Cardiomyocyte-Derived Cell Lines by Inducing Heme Oxygenase 1. Int J Mol Sci. 2020; 21(20). PMC: 7589052. DOI: 10.3390/ijms21207687. View

14.

Wang N, Chen C, Yang D, Liao Q, Luo H, Wang X . Mesenchymal stem cells-derived extracellular vesicles, via miR-210, improve infarcted cardiac function by promotion of angiogenesis. Biochim Biophys Acta Mol Basis Dis. 2017; 1863(8):2085-2092. DOI: 10.1016/j.bbadis.2017.02.023. View

15.

Zhang B, Sun C, Liu Y, Bai F, Tu T, Liu Q . Exosomal miR-27b-3p Derived from Hypoxic Cardiac Microvascular Endothelial Cells Alleviates Rat Myocardial Ischemia/Reperfusion Injury through Inhibiting Oxidative Stress-Induced Pyroptosis via Foxo1/GSDMD Signaling. Oxid Med Cell Longev. 2022; 2022:8215842. PMC: 9279077. DOI: 10.1155/2022/8215842. View

16.

Song Y, Zhang C, Zhang J, Jiao Z, Dong N, Wang G . Localized injection of miRNA-21-enriched extracellular vesicles effectively restores cardiac function after myocardial infarction. Theranostics. 2019; 9(8):2346-2360. PMC: 6531307. DOI: 10.7150/thno.29945. View

17.

Thery C . Exosomes: secreted vesicles and intercellular communications. F1000 Biol Rep. 2011; 3:15. PMC: 3155154. DOI: 10.3410/B3-15. View

18.

Ge X, Meng Q, Zhuang R, Yuan D, Liu J, Lin F . Circular RNA expression alterations in extracellular vesicles isolated from murine heart post ischemia/reperfusion injury. Int J Cardiol. 2019; 296:136-140. DOI: 10.1016/j.ijcard.2019.08.024. View

19.

Mao C, Zhang T, Li D, Zhou E, Fan Y, He Q . Extracellular vesicles from hypoxia-preconditioned mesenchymal stem cells alleviates myocardial injury by targeting thioredoxin-interacting protein-mediated hypoxia-inducible factor-1α pathway. World J Stem Cells. 2022; 14(2):183-199. PMC: 8963381. DOI: 10.4252/wjsc.v14.i2.183. View

20.

Xuan W, Khan M, Ashraf M . Extracellular Vesicles From Notch Activated Cardiac Mesenchymal Stem Cells Promote Myocyte Proliferation and Neovasculogenesis. Front Cell Dev Biol. 2020; 8:11. PMC: 7047205. DOI: 10.3389/fcell.2020.00011. View