Personal Exposure to Source-Specific Particulate Polycyclic Aromatic Hydrocarbons and Systemic Inflammation: A Cross-Sectional Study of Urban-Dwelling Older Adults in China

Overview

Journal Geohealth

Date 2023 Dec 21

PMID 38124775

Authors

Jia Xu

Nan Zhang

Yujuan Zhang

Penghui Li

Jinbao Han

Shuang Gao

Xinhua Wang

Chunmei Geng

Wen Yang

Liwen Zhang

Bin Han

Zhipeng Bai

Affiliations

Soon will be listed here.

Abstract

Environmental exposure to ambient polycyclic aromatic hydrocarbons (PAHs) can disturb the immune response. However, the evidence on adverse health effects caused by exposure to PAHs emitted from specific sources among different vulnerable subpopulations is limited. In this cross-sectional study, we aimed to evaluate whether exposure to source-specific PAHs could increase systemic inflammation in older adults. The present study included community-dwelling older adults and collected ﬁlter samples of personal exposure to PM during the winter of 2011. Blood samples were collected after the PM sample collection. We analyzed PM bound PAHs and serum inflammatory cytokines (interleukin (IL)1β, IL6, and tumor necrosis factor alpha levels. The Positive Matrix Factorization model was used to identify PAH sources. We used a linear regression model to assess the relative eﬀects of source-specific PM bound PAHs on the levels of measured inflammatory cytokines. After controlling for confounders, exposure to PAHs emitted from biomass burning or diesel vehicle emission was significantly associated with increased serum inflammatory cytokines and systemic inflammation. These findings highlight the importance of considering exposure sources in epidemiological studies and controlling exposures to organic materials from specific sources.

Citing Articles

Personal Exposure to Source-Specific Particulate Polycyclic Aromatic Hydrocarbons and Systemic Inflammation: A Cross-Sectional Study of Urban-Dwelling Older Adults in China.

Xu J, Zhang N, Zhang Y, Li P, Han J, Gao S Geohealth. 2023; 7(12):e2023GH000933.

PMID: 38124775 PMC: 10731620. DOI: 10.1029/2023GH000933.

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