Neuro-bone Tissue Engineering: Emerging Mechanisms, Potential Strategies, and Current Challenges

Overview

Journal Bone Res

Specialties Endocrinology
Orthopedics

Date 2023 Dec 20

PMID 38123549

Authors

Wenzhe Sun

Bing Ye

Siyue Chen

Lian Zeng

Hongwei Lu

Yizhou Wan

Qing Gao

Kaifang Chen

Yanzhen Qu

Bin Wu

Xiao Lv

Xiaodong Guo

Affiliations

Soon will be listed here.

Abstract

The skeleton is a highly innervated organ in which nerve fibers interact with various skeletal cells. Peripheral nerve endings release neurogenic factors and sense skeletal signals, which mediate bone metabolism and skeletal pain. In recent years, bone tissue engineering has increasingly focused on the effects of the nervous system on bone regeneration. Simultaneous regeneration of bone and nerves through the use of materials or by the enhancement of endogenous neurogenic repair signals has been proven to promote functional bone regeneration. Additionally, emerging information on the mechanisms of skeletal interoception and the central nervous system regulation of bone homeostasis provide an opportunity for advancing biomaterials. However, comprehensive reviews of this topic are lacking. Therefore, this review provides an overview of the relationship between nerves and bone regeneration, focusing on tissue engineering applications. We discuss novel regulatory mechanisms and explore innovative approaches based on nerve-bone interactions for bone regeneration. Finally, the challenges and future prospects of this field are briefly discussed.

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