Research Progress on Ferroptosis in Gliomas (Review)

Overview

Journal Oncol Lett

Specialty Oncology

Date 2023 Dec 18

PMID 38108075

Authors

Yujie Bo

Luyan Mu

Zhao Yang

Wenhao Li

Ming Jin

Affiliations

Soon will be listed here.

Abstract

Glioma is the most prevalent type of brain tumor characterized by a poor 5-year survival rate and a high mortality rate. Malignant gliomas are commonly treated by surgery, chemotherapy and radiotherapy. However, due to toxicity and resistance to chemoradiotherapy, these treatments can be ineffective. Anxiety and depression are highly prevalent in patients with glioma, adversely affecting disease prognosis and posing societal concerns. Ferroptosis is a type of non-apoptotic, iron-dependent cell death characterized by the accumulation of lethal reactive oxygen species produced by iron metabolism, and it serves a key role in numerous diseases. Regulation of iron phagocytosis may serve as a therapeutic strategy for the development of novel glioma treatments. The present review discusses the mechanisms underlying the occurrence and regulation of ferroptosis, its role in the genesis and evolution of gliomas, and its association with glioma-related anxiety and depression. By exploring potential targets for glioma treatment, the present review provides a theoretical basis for the development of novel therapeutic strategies against glioma.

Citing Articles

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The interplay between metal ions and immune cells in glioma: pathways to immune escape.

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References

Doll S, Porto Freitas F, Shah R, Aldrovandi M, Costa Da Silva M, Ingold I . FSP1 is a glutathione-independent ferroptosis suppressor. Nature. 2019; 575(7784):693-698. DOI: 10.1038/s41586-019-1707-0. View

Gathinji M, McGirt M, Attenello F, Chaichana K, Than K, Olivi A . Association of preoperative depression and survival after resection of malignant brain astrocytoma. Surg Neurol. 2008; 71(3):299-303, discussion 303. DOI: 10.1016/j.surneu.2008.07.016. View

Dixon S, Lemberg K, Lamprecht M, Skouta R, Zaitsev E, Gleason C . Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012; 149(5):1060-72. PMC: 3367386. DOI: 10.1016/j.cell.2012.03.042. View

Wong B, Tsatsanis A, Lim L, Adlard P, Bush A, Duce J . β-Amyloid precursor protein does not possess ferroxidase activity but does stabilize the cell surface ferrous iron exporter ferroportin. PLoS One. 2014; 9(12):e114174. PMC: 4252103. DOI: 10.1371/journal.pone.0114174. View

Conrad M, Lorenz S, Proneth B . Targeting Ferroptosis: New Hope for As-Yet-Incurable Diseases. Trends Mol Med. 2020; 27(2):113-122. DOI: 10.1016/j.molmed.2020.08.010. View

Skjorringe T, Moller L, Moos T . Impairment of interrelated iron- and copper homeostatic mechanisms in brain contributes to the pathogenesis of neurodegenerative disorders. Front Pharmacol. 2012; 3:169. PMC: 3456798. DOI: 10.3389/fphar.2012.00169. View

Zhou Y, Fang C, Xu H, Yuan L, Liu Y, Wang X . Ferroptosis in glioma treatment: Current situation, prospects and drug applications. Front Oncol. 2022; 12:989896. PMC: 9557197. DOI: 10.3389/fonc.2022.989896. View

Alim I, Caulfield J, Chen Y, Swarup V, Geschwind D, Ivanova E . Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke. Cell. 2019; 177(5):1262-1279.e25. DOI: 10.1016/j.cell.2019.03.032. View

Liu X, Yang F, Haile D . Functional consequences of ferroportin 1 mutations. Blood Cells Mol Dis. 2005; 35(1):33-46. DOI: 10.1016/j.bcmd.2005.04.005. View

10.

Ingold I, Berndt C, Schmitt S, Doll S, Poschmann G, Buday K . Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis. Cell. 2018; 172(3):409-422.e21. DOI: 10.1016/j.cell.2017.11.048. View

11.

Shin D, Lee J, You J, Kim D, Roh J . Dihydrolipoamide dehydrogenase regulates cystine deprivation-induced ferroptosis in head and neck cancer. Redox Biol. 2020; 30:101418. PMC: 6957841. DOI: 10.1016/j.redox.2019.101418. View

12.

Han Z, Wang H, Long J, Qiu Y, Xing X . Establishing a prognostic model of ferroptosis- and immune-related signatures in kidney cancer: A study based on TCGA and ICGC databases. Front Oncol. 2022; 12:931383. PMC: 9459019. DOI: 10.3389/fonc.2022.931383. View

13.

Sun X, Ou Z, Chen R, Niu X, Chen D, Kang R . Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells. Hepatology. 2015; 63(1):173-84. PMC: 4688087. DOI: 10.1002/hep.28251. View

14.

Maes M, Kubera M, Obuchowiczwa E, Goehler L, Brzeszcz J . Depression's multiple comorbidities explained by (neuro)inflammatory and oxidative & nitrosative stress pathways. Neuro Endocrinol Lett. 2011; 32(1):7-24. View

15.

Luo Y, Tian G, Fang X, Bai S, Yuan G, Pan Y . Ferroptosis and Its Potential Role in Glioma: From Molecular Mechanisms to Therapeutic Opportunities. Antioxidants (Basel). 2022; 11(11). PMC: 9686959. DOI: 10.3390/antiox11112123. View

16.

Ma S, Henson E, Chen Y, Gibson S . Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells. Cell Death Dis. 2016; 7:e2307. PMC: 4973350. DOI: 10.1038/cddis.2016.208. View

17.

Yi R, Wang H, Deng C, Wang X, Yao L, Niu W . Dihydroartemisinin initiates ferroptosis in glioblastoma through GPX4 inhibition. Biosci Rep. 2020; 40(6). PMC: 7313443. DOI: 10.1042/BSR20193314. View

18.

Treudler R, Zeynalova S, Riedel-Heller S, Zuelke A, Roehr S, Hinz A . Depression, anxiety and quality of life in subjects with atopic eczema in a population-based cross-sectional study in Germany. J Eur Acad Dermatol Venereol. 2019; 34(4):810-816. DOI: 10.1111/jdv.16148. View

19.

Sukseree S, Schwarze U, Gruber R, Gruber F, Del Rey M, Mancias J . ATG7 is essential for secretion of iron from ameloblasts and normal growth of murine incisors during aging. Autophagy. 2019; 16(10):1851-1857. PMC: 8386597. DOI: 10.1080/15548627.2019.1709764. View

20.

Roh J, Kim E, Jang H, Shin D . Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis. Redox Biol. 2016; 11:254-262. PMC: 5198738. DOI: 10.1016/j.redox.2016.12.010. View