Lipid Compartments and Lipid Metabolism As Therapeutic Targets Against Coronavirus

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2023 Dec 18

PMID 38106410

Authors

Daniella Cesar-Silva

Filipe S Pereira-Dutra

Ana Lucia Moraes Giannini

Clarissa M Maya-Monteiro

Cecilia Jacques G de Almeida

Affiliations

Soon will be listed here.

Abstract

Lipids perform a series of cellular functions, establishing cell and organelles' boundaries, organizing signaling platforms, and creating compartments where specific reactions occur. Moreover, lipids store energy and act as secondary messengers whose distribution is tightly regulated. Disruption of lipid metabolism is associated with many diseases, including those caused by viruses. In this scenario, lipids can favor virus replication and are not solely used as pathogens' energy source. In contrast, cells can counteract viruses using lipids as weapons. In this review, we discuss the available data on how coronaviruses profit from cellular lipid compartments and why targeting lipid metabolism may be a powerful strategy to fight these cellular parasites. We also provide a formidable collection of data on the pharmacological approaches targeting lipid metabolism to impair and treat coronavirus infection.

Citing Articles

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PMID: 38932200 PMC: 11209218. DOI: 10.3390/v16060908.

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