Intestinal Acetate and Butyrate Availability is Associated with Glucose Metabolism in Healthy Individuals

Overview

Journal iScience

Publisher Cell Press

Date 2023 Dec 14

PMID 38094244

Authors

Madelief Wijdeveld

Anouk Schrantee

Anouk Hagemeijer

Aart J Nederveen

Torsten P M Scheithauer

Johannes H M Levels

Andrei Prodan

Willem M de Vos

Max Nieuwdorp

Richard G IJzerman

Affiliations

Soon will be listed here.

Abstract

Animal studies suggest that short-chain fatty acids acetate and butyrate are key players in the gut-brain axis and may affect insulin sensitivity. We investigated the association of intestinal acetate and butyrate availability (measured by butyryl-coenzyme A transferase (ButCoA) gene amount) with insulin sensitivity and secretion in healthy subjects from the HELIUS cohort study from the highest 15% (N = 30) and the lowest 15% (N = 30) intestinal ButCoA gene amount. The groups did not differ in insulin sensitivity or secretion. However, the high ButCoA group showed lower glucose and insulin peaks during the first 60 min after a meal and a higher nadir during the second 60 min (p < 0.01), suggesting delayed glucose adsorption from the small intestine. Our data suggest that chronically increased acetate and butyrate availability may improve glucose metabolism by delaying gastric emptying and intestinal adsorption. Future studies should further investigate the effect of acetate and butyrate interventions.

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