Emerging Functions and Significance of CircCDYL in Human Disorders

Overview

Journal Mol Biol Rep

Specialty Molecular Biology

Date 2023 Dec 12

PMID 38085365

Authors

Sheyda Khalilian

Mohammad Amin Khazeei Tabari

Mohammad Amin Omrani

Soudeh Ghafouri-Fard

Affiliations

Soon will be listed here.

Abstract

Circular RNAs (circRNAs) are a group of non-coding transcripts in which a loop structure is shaped via a back splicing procedure. They have central roles in the regulation of gene expression. hsa_circ_0008285, alternatively named as circCDYL, is a circular RNA originated from the exon 4 of CDYL gene. It is produced by a back-splice incident and is mainly located in the cytoplasm. It has no internal ribosome entry site, open reading frame and intronic sequences. CircCDYL dysregulation has been reported in the malignant conditions including multiple myeloma, mantle cell lymphoma, breast cancer, non-small cell lung cancer, Wilms tumor, bladder cancer, colon cancer, and hepatocellular carcinoma. It also has an emerging role in the pathophysiology of non-malignant conditions including myocardial infarction, gestational diabetes mellitus, membranous nephropathy, and abdominal aortic aneurysm. In the current study, we summarize the emerging roles of circCDYL in malignant and non-malignant conditions.

Citing Articles

Implications in Cancer of Nuclear Micro RNAs, Long Non-Coding RNAs, and Circular RNAs Bound by PRC2 and FUS.

Swaminathan G, Rogel-Ayala D, Armich A, Barreto G Cancers (Basel). 2024; 16(5).

PMID: 38473229 PMC: 10930775. DOI: 10.3390/cancers16050868.

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