The Emerging Role of the Interactions Between Circular RNAs and RNA-binding Proteins in Common Human Cancers

Overview

Journal J Cancer

Specialty Oncology

Date 2021 Aug 2

PMID 34335937

Citations 17

Authors

Meng-Ping Jiang

Wen-Xiu Xu

Jun-Chen Hou

Qi Xu

Dan-Dan Wang

Jin-Hai Tang

Affiliations

Soon will be listed here.

Abstract

Circular RNAs (circRNAs) are a unique family of noncoding RNAs that could regulate multiple biological processes, which play a crucial role in carcinogenesis, progression and chemotherapy resistance of cancers. Growing studies have demonstrated that circRNAs act as novel biomarkers and therapeutic targets for cancers by sponging microRNAs (miRNAs). Up to date, another function of circRNAs, combining with RNA-binding proteins (RBPs), was uncovered. However, there is limit studies illustrating the underlying mechanism of circRNAs-RBPs interactions, as well as showing its roles in diverse types of cancers. In this review, we collected the biogenesis, properties of circRNAs, and then synthesize the connection between circRNAs and RBPs, and try to clarify its molecular mechanisms involving in the pathogenesis and progression of several common cancers, aiming to provide a brand-new insight to the prognosis and treatment strategy for cancers.

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