RNA MA Methylation and MDSCs: Roles and Therapeutic Implications for Radiotherapy

Overview

Journal Med

Publisher Cell Press

Specialty General Medicine

Date 2023 Dec 9

PMID 38070481

Authors

Liangliang Wang

Rohan R Katipally

Hua Laura Liang

Kaiting Yang

Sean P Pitroda

Chuan He

Ralph R Weichselbaum

Affiliations

Soon will be listed here.

Abstract

Emerging evidence suggests that local tumor radiotherapy reshapes the repertoire of circulating myeloid-derived suppressor cells (MDSCs) and leads to their infiltration into the tumor microenvironment, which poses a major obstacle for radiotherapy efficacy. Recent findings have identified RNA mA modification at the nexus of both anti-tumor immunity and radiation response. Here, we examine the mechanisms by which this RNA modification modulates the immune milieu of the radiation-remodeled tumor microenvironment. We discuss potential therapeutic interventions targeting mA machinery to improve radiotherapy response.

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