The Multifaceted Roles of Lamins in Lung Cancer and DNA Damage Response

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2023 Dec 9

PMID 38067205

Authors

Janina Janetzko

Sebastian Oeck

Alexander Schramm

Affiliations

Soon will be listed here.

Abstract

Emerging evidence suggests that lamin functions are not limited to maintaining the structural integrity of the nucleus in eukaryotic cells but that these functions affect many facets of cancer biology. An increasing number of reports suggest that adaptive changes in the lamin subtype composition within the nuclear lamina could affect essential features of cancer development and aggressiveness. These include regulation of cellular stiffness and mobility as well as epithelial-to-mesenchymal transition (EMT), all of which directly impact the metastatic properties of cancer cells. Additionally, insights from studies on the physiological functions of lamins suggest that cancer cells could hijack the ability of lamins to modify chromatin accessibility, cell cycle regulation, and DNA damage response. Here, we present a comprehensive overview of the role of lamins in lung cancer and DNA damage response, which is commonly evoked by lung cancer therapies. Collectively, this information should help better understand the sometimes-conflicting reports on lamin functions in lung cancer as well as in other cancer types.

Citing Articles

Divergent Contribution of Cytoplasmic Actins to Nuclear Structure of Lung Cancer Cells.

Shagieva G, Dugina V, Burakov A, Levuschkina Y, Kudlay D, Boichuk S Int J Mol Sci. 2025; 25(24.

PMID: 39769373 PMC: 11727787. DOI: 10.3390/ijms252413607.

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