Effects of Bilateral Repetitive Transcranial Magnetic Stimulation on Prospective Memory in Patients with Schizophrenia: A Double-blind Randomized Controlled Clinical Trial

Overview

Journal Neuropsychopharmacol Rep

Specialties Neurology
Pharmacology

Date 2023 Dec 6

PMID 38053478

Authors

Fen Xue

Xin-Fu Wang

Fan-Ni Kong

Tian-Lu Yin

Yu-Hong Wang

Li-Da Shi

Xiao-Wen Liu

Hui-Jing Yu

Li-Jun Liu

Ping Zhu

Xiao-Xue Qi

Xue-Jing Xu

Hong-Pu Hu

Su-Xia Li

Affiliations

Soon will be listed here.

Abstract

Aims: To investigate effects of repetitive transcranial magnetic stimulation (rTMS) on the prospective memory (PM) in patients with schizophrenia (SCZ).

Methods: Fifty of 71 patients completed this double-blind placebo-controlled randomized trial and compared with 18 healthy controls' (HCs) PM outcomes. Bilateral 20 Hz rTMS to the dorsolateral prefrontal cortex at 90% RMT administered 5 weekdays for 4 weeks for a total of 20 treatments. The Positive and Negative Symptom Scale (PANSS), the Scale for the Assessment of Negative Symptoms (SANS), and PM test were assessed before and after treatment.

Results: Both Event-based PM (EBPM) and Time-based PM (TBPM) scores at baseline were significantly lower in patients with SCZ than that in HCs. After rTMS treatments, the scores of EBPM in patients with SCZ was significantly improved and had no differences from that in HCs, while the scores of TBPM did not improved. The negative symptom scores on PANSS and the scores of almost all subscales and total scores of SANS were significantly improved in both groups.

Conclusions: Our findings indicated that bilateral high-frequency rTMS treatment can alleviate EBPM but not TBPM in patients with SCZ, as well as improve the negative symptoms.

Significance: Our results provide one therapeutic option for PM in patients with SCZ.

Citing Articles

Effects of bilateral repetitive transcranial magnetic stimulation on prospective memory in patients with schizophrenia: A double-blind randomized controlled clinical trial.

Xue F, Wang X, Kong F, Yin T, Wang Y, Shi L Neuropsychopharmacol Rep. 2023; 44(1):97-108.

PMID: 38053478 PMC: 10932802. DOI: 10.1002/npr2.12397.

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