Synthesis Technology of Magnesium-Doped Nanometer Hydroxyapatite: A Review

Overview

Journal ACS Omega

Publisher American Chemical Society

Specialty Chemistry

Date 2023 Dec 4

PMID 38046298

Authors

Kui Zhang

Yan Liu

Zhenrui Zhao

Xuewen Shi

Ruihao Zhang

Yixiang He

Huaibin Zhang

Yi Sun

Wenji Wang

Affiliations

Soon will be listed here.

Abstract

Ion substitution techniques for nanoparticles have become an important neighborhood of biomedical engineering and have led to the development of innovative bioactive materials for health systems. Magnesium-doped nanohydroxyapatite (Mg-nHA) has good bone conductivity, biological activity, flexural strength, and fracture toughness due to particle doping technology, making it an ideal candidate material for biomedical applications. In this Review, we have systematically presented the synthesis methods of Mg-nHA and their application in the field of biomedical science and highlighted the pros and cons of each method. Finally, some future prospects for this important neighborhood are proposed. The purpose of this Review is to provide readers with an understanding of this new field of research on bioactive materials with innovative functions and systematically introduce the latest technologies for obtaining uniform, continuous, and morphologically diverse Mg-nHA.

Citing Articles

Visible Light-Sensitive Sustainable Quantum Dot Crystals of Co/Mg Doped Natural Hydroxyapatite Possessing Antimicrobial Activity and Biocompatibility.

Maleki-Ghaleh H, Kaminski B, Moradpur-Tari E, Raza S, Khanmohammadi M, Zbonikowski R Small. 2024; 20(52):e2405708.

PMID: 39449217 PMC: 11673459. DOI: 10.1002/smll.202405708.

Natural Nano-Minerals (NNMs): Conception, Classification and Their Biomedical Composites.

Feng F, Zhang Y, Zhang X, Mu B, Qu W, Wang P ACS Omega. 2024; 9(16):17760-17783.

PMID: 38680370 PMC: 11044256. DOI: 10.1021/acsomega.4c00674.

References

Dittler M, Unalan I, Grunewald A, Beltran A, Grillo C, Destch R . Bioactive glass (45S5)-based 3D scaffolds coated with magnesium and zinc-loaded hydroxyapatite nanoparticles for tissue engineering applications. Colloids Surf B Biointerfaces. 2019; 182:110346. DOI: 10.1016/j.colsurfb.2019.110346. View

Wang J, Witte F, Xi T, Zheng Y, Yang K, Yang Y . Recommendation for modifying current cytotoxicity testing standards for biodegradable magnesium-based materials. Acta Biomater. 2015; 21:237-49. DOI: 10.1016/j.actbio.2015.04.011. View

Ahmadzadeh E, Talebnia F, Tabatabaei M, Ahmadzadeh H, Mostaghaci B . Osteoconductive composite graft based on bacterial synthesized hydroxyapatite nanoparticles doped with different ions: From synthesis to in vivo studies. Nanomedicine. 2016; 12(5):1387-95. DOI: 10.1016/j.nano.2016.01.020. View

Sedghi R, Shaabani A, Sayyari N . Electrospun triazole-based chitosan nanofibers as a novel scaffolds for bone tissue repair and regeneration. Carbohydr Polym. 2020; 230:115707. DOI: 10.1016/j.carbpol.2019.115707. View

Bhat S, Uthappa U, Altalhi T, Jung H, Kurkuri M . Functionalized Porous Hydroxyapatite Scaffolds for Tissue Engineering Applications: A Focused Review. ACS Biomater Sci Eng. 2021; 8(10):4039-4076. DOI: 10.1021/acsbiomaterials.1c00438. View

Pogorielov M, Husak E, Solodivnik A, Zhdanov S . Magnesium-based biodegradable alloys: Degradation, application, and alloying elements. Interv Med Appl Sci. 2017; 9(1):27-38. PMC: 5598119. DOI: 10.1556/1646.9.2017.1.04. View

Ren F, Leng Y, Xin R, Ge X . Synthesis, characterization and ab initio simulation of magnesium-substituted hydroxyapatite. Acta Biomater. 2009; 6(7):2787-96. DOI: 10.1016/j.actbio.2009.12.044. View

Ma J, Wang J, Ai X, Zhang S . Biomimetic self-assembly of apatite hybrid materials: from a single molecular template to bi-/multi-molecular templates. Biotechnol Adv. 2013; 32(4):744-60. DOI: 10.1016/j.biotechadv.2013.10.014. View

Rial R, Gonzalez-Durruthy M, Liu Z, Ruso J . Advanced Materials Based on Nanosized Hydroxyapatite. Molecules. 2021; 26(11). PMC: 8198166. DOI: 10.3390/molecules26113190. View

10.

Neacsu I, Stoica A, Vasile B, Andronescu E . Luminescent Hydroxyapatite Doped with Rare Earth Elements for Biomedical Applications. Nanomaterials (Basel). 2019; 9(2). PMC: 6409594. DOI: 10.3390/nano9020239. View

11.

Qu H, Fu H, Han Z, Sun Y . Biomaterials for bone tissue engineering scaffolds: a review. RSC Adv. 2022; 9(45):26252-26262. PMC: 9070423. DOI: 10.1039/c9ra05214c. View

12.

Jokanovic V, Izvonar D, Dramicanin M, Jokanovic B, Zivojinovic V, Markovic D . Hydrothermal synthesis and nanostructure of carbonated calcium hydroxyapatite. J Mater Sci Mater Med. 2006; 17(6):539-46. DOI: 10.1007/s10856-006-8937-z. View

13.

Qu X, Yang H, Yu Z, Jia B, Qiao H, Zheng Y . Serum zinc levels and multiple health outcomes: Implications for zinc-based biomaterials. Bioact Mater. 2020; 5(2):410-422. PMC: 7114479. DOI: 10.1016/j.bioactmat.2020.03.006. View

14.

G A, P N, R S, R S . Multi-ionic interaction with magnesium doped hydroxyapatite-zeolite nanocomposite porous polyacrylonitrile polymer bead in aqueous solution and spiked groundwater. Environ Pollut. 2022; 309:119728. DOI: 10.1016/j.envpol.2022.119728. View

15.

Shyngys M, Ren J, Liang X, Miao J, Blocki A, Beyer S . Metal-Organic Framework (MOF)-Based Biomaterials for Tissue Engineering and Regenerative Medicine. Front Bioeng Biotechnol. 2021; 9:603608. PMC: 7991400. DOI: 10.3389/fbioe.2021.603608. View

16.

Shoba E, Lakra R, Kiran M, Korrapati P . 3 D nano bilayered spatially and functionally graded scaffold impregnated bromelain conjugated magnesium doped hydroxyapatite nanoparticle for periodontal regeneration. J Mech Behav Biomed Mater. 2020; 109:103822. DOI: 10.1016/j.jmbbm.2020.103822. View

17.

Munir Z . 1000 at 1000: The effect of electric field and pressure on the synthesis and consolidation of materials: a review of the spark plasma sintering method. J Mater Sci. 2020; 55(32):15365-15366. PMC: 7351546. DOI: 10.1007/s10853-020-05040-4. View

18.

Sindoro M, Yanai N, Jee A, Granick S . Colloidal-sized metal-organic frameworks: synthesis and applications. Acc Chem Res. 2013; 47(2):459-69. DOI: 10.1021/ar400151n. View

19.

Lilley K, Gbureck U, Knowles J, Farrar D, Barralet J . Cement from magnesium substituted hydroxyapatite. J Mater Sci Mater Med. 2005; 16(5):455-60. DOI: 10.1007/s10856-005-6986-3. View

20.

Lamkhao S, Phaya M, Jansakun C, Chandet N, Thongkorn K, Rujijanagul G . Synthesis of Hydroxyapatite with Antibacterial Properties Using a Microwave-Assisted Combustion Method. Sci Rep. 2019; 9(1):4015. PMC: 6408465. DOI: 10.1038/s41598-019-40488-8. View