Cement from Magnesium Substituted Hydroxyapatite

Overview

Journal J Mater Sci Mater Med

Publisher Springer

Specialty Biomedical Engineering

Date 2005 May 6

PMID 15875256

Citations 10

Authors

K J Lilley

U Gbureck

J C Knowles

D F Farrar

J E Barralet

Affiliations

Soon will be listed here.

Abstract

Brushite cement may be used as a bone graft material and is more soluble than apatite in physiological conditions. Consequently it is considerably more resorbable in vivo than apatite forming cements. Brushite cement formation has previously been reported by our group following the mixture of nanocrystalline hydroxyapatite and phosphoric acid. In this study, brushite cement was formed from the reaction of nanocrystalline magnesium-substituted hydroxyapatite with phosphoric acid in an attempt to produce a magnesium substituted brushite cement. The presence of magnesium was shown to have a strong effect on cement composition and strength. Additionally the presence of magnesium in brushite cement was found to reduce the extent of brushite hydrolysis resulting in the formation of HA. By incorporating magnesium ions in the apatite reactant structure the concentration of magnesium ions in the liquid phase of the cement was controlled by the dissolution rate of the apatite. This approach may be used to supply other ions to cement systems during setting as a means to manipulate the clinical performance and characteristics of brushite cements.

Citing Articles

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In vivo biocompatibility of SrO and MgO doped brushite cements.

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Olkowski R, Kaszczewski P, Czechowska J, Siek D, Pijocha D, Zima A J Mater Sci Mater Med. 2015; 26(12):270.

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Self-setting calcium orthophosphate formulations.

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