Relationship of HLA Protein Display to Activation of 2-5A Synthetase in HBe Antigen or Anti-HBe Positive Chronic HBV Infection

Overview

Journal Gut

Specialty Gastroenterology

Date 1986 Dec 1

PMID 3804026

Citations 7

Authors

T Ikeda

M Pignatelli

A M Lever

H C Thomas

Affiliations

Soon will be listed here.

Abstract

In this study we have examined the density of HLA class I protein display on the hepatocytes of patients with HBe antigen (HBeAg) or anti-HBe (HBeAb) positive chronic hepatitis B virus (HBV) infection and related this to the level of interferon activation of these cells determined by measuring hepatic oligo 2-5A synthetase activity. In HBeAg positive patients the density of HLA class I (HLA-I) protein was not significantly increased above that found in uninfected liver, but levels of 2-5A synthetase were twice normal. In anti-HBe positive patients, HLA-I density was markedly increased in the presence of normal 2-5A synthetase activity. These data are consistent with type I (alpha or beta) interferon activation of the hepatocytes in HBeAg positive patients and type II (gamma) interferon activity in anti-HBe positive subjects.

Citing Articles

Interferon in the management of chronic hepatitis B.

Perrillo R Dig Dis Sci. 1993; 38(4):577-93.

PMID: 8462360 DOI: 10.1007/BF01316785.

Effects of cytokines on HLA class I antigen expression on Huh6 and HB611 cells.

Towata T, Hayashi N, Katayama K, Takehara T, Miyoshi E, Kawanishi Y Gastroenterol Jpn. 1993; 28(2):242-8.

PMID: 8387437 DOI: 10.1007/BF02779226.

Alpha-interferon enhances gamma-interferon production of peripheral blood mononuclear cells pre-activated with phytohemagglutinin.

Katayama K, Hayashi N, Takehara T, Suzuki K, Kasahara A, Fusamoto H Gastroenterol Jpn. 1993; 28(5):673-8.

PMID: 8224618 DOI: 10.1007/BF02806348.

Effect of recombinant interleukin 2 on hepatitis B e antigen positive chronic hepatitis.

Onji M, Kondoh H, Horiike N, Yamaguchi S, Ogawa Y, Kumon I Gut. 1987; 28(12):1648-52.

PMID: 3501387 PMC: 1433944. DOI: 10.1136/gut.28.12.1648.

Liver lesions in hepatitis B viral infection.

Desmet V Yale J Biol Med. 1988; 61(1):61-83.

PMID: 2834884 PMC: 2590411.

References

Weller I, Bassendine M, Murray A, Craxi A, Thomas H, Sherlock S . Effects of prednisolone/azathioprine in chronic hepatitis B viral infection. Gut. 1982; 23(8):650-5. PMC: 1419130. DOI: 10.1136/gut.23.8.650. View

Grossberg S . The interferons and their inducers: molecular and therapeutic considerations. 1. N Engl J Med. 1972; 287(1):13-9. DOI: 10.1056/NEJM197207062870104. View

Liaw Y, Chu C, Su I, Huang M, Lin D . Clinical and histological events preceding hepatitis B e antigen seroconversion in chronic type B hepatitis. Gastroenterology. 1983; 84(2):216-9. View

Pignatelli M, Waters J, Brown D, Lever A, Iwarson S, Schaff Z . HLA class I antigens on the hepatocyte membrane during recovery from acute hepatitis B virus infection and during interferon therapy in chronic hepatitis B virus infection. Hepatology. 1986; 6(3):349-53. DOI: 10.1002/hep.1840060303. View

Wheelock E . Interferon-Like Virus-Inhibitor Induced in Human Leukocytes by Phytohemagglutinin. Science. 1965; 149(3681):310-1. DOI: 10.1126/science.149.3681.310. View

Lengyel P . Biochemistry of interferons and their actions. Annu Rev Biochem. 1982; 51:251-82. DOI: 10.1146/annurev.bi.51.070182.001343. View

Schattner A, Wallach D, Merlin G, Hahn T, Levin S, Ramot B . Variation of (2'-5') oligo A synthetase level in lymphocytes and granulocytes of patients with viral infections and leukemia. J Interferon Res. 1982; 2(3):355-61. DOI: 10.1089/jir.1982.2.355. View

Montano L, Miescher G, Goodall A, Wiedmann K, Janossy G, Thomas H . Hepatitis B virus and HLA antigen display in the liver during chronic hepatitis B virus infection. Hepatology. 1982; 2(5):557-61. DOI: 10.1002/hep.1840020508. View

Broeze R, Dougherty J, Pichon J, Jayaram B, Lengyel P . Studies with pure mouse Ehrlich ascites tumor interferons alpha and beta: patterns of induction of (2'-5') (A)n synthetase and of a double-stranded RNA-dependent protein kinase in mouse cells and human cells. J Interferon Res. 1981; 1(2):191-202. DOI: 10.1089/jir.1981.1.191. View

10.

BRANCA A, Baglioni C . Evidence that types I and II interferons have different receptors. Nature. 1981; 294(5843):768-70. DOI: 10.1038/294768a0. View

11.

Barnstable C, Bodmer W, Brown G, Galfre G, Milstein C, Williams A . Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis. Cell. 1978; 14(1):9-20. DOI: 10.1016/0092-8674(78)90296-9. View

12.

Toy J . The interferons. Clin Exp Immunol. 1983; 54(1):1-13. PMC: 1536188. View

13.

Wallach D, Fellous M, Revel M . Preferential effect of gamma interferon on the synthesis of HLA antigens and their mRNAs in human cells. Nature. 1982; 299(5886):833-6. DOI: 10.1038/299833a0. View

14.

Durandy A, Virelizier J, Griscelli C . Enhancement by interferon of membrane HLA antigens in patients with combined immunodeficiency with defective HLA expression. Clin Exp Immunol. 1983; 52(1):173-8. PMC: 1535567. View

15.

Heron I, Hokland M, Berg K . Enhanced expression of beta2-microglobulin and HLA antigens on human lymphoid cells by interferon. Proc Natl Acad Sci U S A. 1978; 75(12):6215-9. PMC: 393150. DOI: 10.1073/pnas.75.12.6215. View

16.

Mondelli M, Vergani G, Alberti A, Vergani D, Portmann B, Eddleston A . Specificity of T lymphocyte cytotoxicity to autologous hepatocytes in chronic hepatitis B virus infection: evidence that T cells are directed against HBV core antigen expressed on hepatocytes. J Immunol. 1982; 129(6):2773-8. View